Tumor-associated tissue eosinophilia in nasopharyngeal carcinoma. A pathologic study of 422 primary and 138 metastatic tumors

Looi, Lai‐Meng

doi:10.1002/1097-0142(19870201)59:3<466::aid-cncr2820590319>3.0.co;2-p

Cited by 51 publications

(37 citation statements)

References 19 publications

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“…However, we should remain alert to the potential of potent Th2-skewing conditions negatively impacting Th1 antitumor adaptive immunity (41,42), as eosinophils have been suggested to possess both anti-and protumorigenic activity. It is, however, difficult to determine the role of eosinophils in tumorigenesis because it can be affected by tumor type (43)(44)(45), and the phase analyzed is often diverse. One hypothesis supposed by the current study and the experiments using IL-5 transgenic mice (30) is that the number of existing eosinophils when tumor cells are inoculated or induced by a carcinogen largely affects the outcome.…”

Section: Discussionmentioning

confidence: 99%

Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

Ikutani

Yanagibashi

Ogasawara

et al. 2012

The Journal of Immunology

273

208

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IL-5 is involved in a number of immune responses such as helminth infection and allergy. IL-5 also plays roles in innate immunity by maintaining B-1 B cells and mucosal IgA production. However, the identity of IL-5–producing cells has not been unambiguously characterized. In this report, we describe the generation of an IL-5 reporter mouse and identify IL-5–producing non-T lymphoid cells that reside in the intestine, peritoneal cavity, and lungs in naive mice. They share many characteristics with natural helper cells, nuocytes, and Ih2 cells, including surface Ags and responsiveness to cytokines. However, these phenotypes do not completely overlap with any particular one of these cell types. Innate non-T IL-5–producing cells localized most abundantly in the lung and proliferated and upregulated IL-5 production in response to IL-25 and IL-33. IL-33 was more effective than IL-25. These cells contribute to maintaining sufficient numbers of lung eosinophils and are important for eosinophil recruitment mediated by IL-25 and IL-33. Given that eosinophils are shown to possess antitumor activity, we studied lung tumor metastasis and showed that innate IL-5–producing cells were increased in response to tumor invasion, and their regulation of eosinophils is critical to suppress tumor metastasis. Genetic blockade or neutralization of IL-5 impaired eosinophil recruitment into the lung and resulted in increased tumor metastasis. Conversely, exogenous IL-5 treatment resulted in suppressed tumor metastasis and augmented eosinophil infiltration. These newly identified innate IL-5–producing cells thus play a role in tumor surveillance through lung eosinophils and may contribute to development of novel immunotherapies for cancer.

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Section: Discussionmentioning

confidence: 99%

Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

Ikutani

Yanagibashi

Ogasawara

et al. 2012

The Journal of Immunology

273

208

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“…Lowe and Fletcher 22 were the first to mention TATE in head and neck cancers, but they did not study the relation between TATE and prognosis. Looi 13 There is no consensus about the classification of TATE, and many investigators use different grading. Lowe and Fletcher 22 and Looi 13 considered more than 10 eosinophils per HPF to be moderate TATE and more than 100 eosinophils per HPF to be massive TATE.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Stromal Eosinophilic Infiltration in Oral Squamous Cell Carcinoma

Andisheh-Tadbir¹,

Ashraf²,

Sardari³

2009

Journal of Craniofacial Surgery

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Tumor-associated tissue eosinophilia (TATE) has been described in many sites, including head and neck. The aim of this study was to investigate the prevalence and possible role of TATE as a prognostic factor in oral squamous cell carcinoma (OSCC). Seventy-six consecutive patients with a diagnosis of OSCC were evaluated, and the number of eosinophils was obtained in 3 different areas in the tumor. The possible role of TATE as a prognostic factor in OSCC was investigated with respect to tumor differentiation; perineural, vascular, and muscular invasion (histopathologic parameters); and locoregional metastasis (clinical parameter). Tumor-associated tissue eosinophilia was low in most cases in 3 different areas. The mean eosinophil count was higher in the invasive front of tumor than intratumoral stroma and stroma subjacent the surface epithelium. The relations between TATE and tumor differentiation; perineural, vascular, and muscular invasion; and locoregional metastasis were not statistically significant (P > 0.05). Tumor-associated tissue eosinophilia has no correlation with prognostic parameters in OSCC.

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“…A concrete consensus on qualifying the TATE categories is not available yet. While some authors specify eosinophil count greater than 10 in 10 HPF as intermediate, a count exceeding 100 is considered as severe [17,19]. In the present study, cases were divided quantitatively into three groups based on the eosinophil count.…”

Section: Resultsmentioning

confidence: 92%

Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

Etıt

Yardim

Arslanoğlu

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Inflammatory infiltration with eosinophilia in or around the tumoral tissue varies among the cases with invasive squamous cell carcinoma of the larynx. The aim of this study was to investigate the possible role of the tumor-associated tissue eosinophilia (TATE) as a predictive factor for the metastatic status in laryngeal squamous cell carcinoma in patients who had neck dissections. One hundred consecutive specimens from the patients who had been treated surgically for invasive squamous cell carcinoma of the larynx were re-evaluated in terms of TATE.

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Tumor-associated tissue eosinophilia in nasopharyngeal carcinoma. A pathologic study of 422 primary and 138 metastatic tumors

Cited by 51 publications

References 19 publications

Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

Identification of Innate IL-5–Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity

Prognostic Significance of Stromal Eosinophilic Infiltration in Oral Squamous Cell Carcinoma

Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

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