Tumor-derived exosomes in colorectal cancer progression and their clinical applications

Zhou, Jianbiao; Li, Xiaolan; Chen, Zhirong; Chng, Wee‐Joo

doi:10.18632/oncotarget.20117

Cited by 53 publications

(57 citation statements)

References 82 publications

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“…EVs are actively involved in cell-to-cell communication, inflammation, chronic disease development and progression, pre-metastatic niche formation, and the metastatic organotropism of different tumor types [8]. Tumor-derived EVs (TEVs) have been reported to play major roles in the onset, progression, and metastasis of cancer, including ovarian [9], breast [10], colorectal [11,12], prostate cancer [13], and melanoma [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles in Cancer

Voichitoiu¹,

Radu²,

Pavelescu³

et al. 2020

Extracellular Vesicles and Their Importance in Human Health

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Extracellular vesicles (EVs) represent a generic term for all the secreted vesicles, which include exosomes, microvesicles, and apoptotic bodies. EVs are key partners in the intercellular communication and play an essential role in multiple physiological and pathological conditions. EVs are shuttles for cargo molecules, such as RNA (mRNA, microRNA, and other noncoding RNAs), DNA, proteins (receptors, transcription factors, enzymes, and extracellular matrix proteins), and lipids. In pathological states, including cancer, EVs might represent either useful biomarkers or can be used for therapeutic purposes. Moreover, in cancer, it was demonstrated that EVs play an essential role in drug resistance. Here, we review the role played by EVs in the most common forms of cancer, with a special focus on ovarian and breast cancers.

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Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles in Cancer

Voichitoiu¹,

Radu²,

Pavelescu³

et al. 2020

Extracellular Vesicles and Their Importance in Human Health

View full text Add to dashboard Cite

show abstract

“…Furthermore, exosomes have been successfully purified from many body fluids such as blood, urine, pleural effusions, ascites and broncoalveolar fluid [ 21 ]. Also, exosomes can transfer information, including DNA, RNA and proteins, to the receptor cells through fusion with the plasma membrane, endocytosis by phagocytic mechanism or receptor-ligand interaction with the cell [ 22 ] and have the heterogeneous biological behaviors due to their different secretory cell types with diverse cell status [ 23 ], thus participating in different physiological and pathological processes. Rab GTPases, including Rab27a and Rab27b, are the key regulators of exosomes secretion and Rab27 is closely related to the occurrence and the development of tumor, which indicates the role of exosomes secretion in tumor biology [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

Zheng

Zhan

Liu

et al. 2018

J Exp Clin Cancer Res

122

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Non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer cases, and it is one of the leading causes of cancer death in both men and women worldwide due to diagnosis in the advanced stage, rapid metastasis, and recurrence. At present, precision molecular targeted therapeutics directed toward NSCLC driven genes has made great progress and significantly improved the overall survival of patients with NSCLC, but can easily lead to acquired drug resistance. New methods are needed to develop real-time monitoring of drug efficacy and drug resistance, such as new molecular markers for more effective early detection and prediction of prognosis. Exosomes are nano-sized extracellular vesicles, containing proteins, nucleic acids and lipids, which are secreted by various cells, and they play an important role in the development of lung cancer by controlling a wide range of pathways. Tumor-derived exosomes are of great significance for guiding the targeted therapy of NSCLC and exosomes themselves can be a target for treatment. In this review, we describe the potential roles of tumor-derived exosomes and their clinical significance in NSCLC.

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“…Plasmonic exosome detection, also known as SPR (Surface Plasmon Resonance), is a highly sensitive method able to detect as low as 1 molecule. Weissleder/Lee group established a sensor named nPLEX (nano plasmonic exosome) that has multiple nanohole arrays that are able to detect all types of exosomes (26,27).…”

Section: • Exosomesmentioning

confidence: 99%

The importance of circulating tumor products as „liquid biopsies” in colorectal cancer

Miscoci¹,

Pirvu²,

Calborean³

et al. 2018

JMMS

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Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Examining such biomarkers in the plasma of colorectal cancer patients has attracted attention due to its clinical significance in the treatment of malignant diseases. Given that tissue samples are sometimes challenging to procure or unsatisfactory for genomic profiling from patients with colorectal cancer, trustworthy biomarkers are mandatory for guiding treatment, monitoring therapeutic response, and detecting recurrence. This review considers the relevance of flowing tumor products like circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating messenger RNA (mRNA), circulating micro RNA (miRNA), circulating exosomes, and tumor educated platelets (TEPs) for patients with colorectal cancer. Keywords  liquid biopsies, circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), colorectal cancer (CRC), circulating exosomes, tumor educated platelets (TEPs) Highlights ✓ Circulating tumor cells and circulating tumor DNA serve as a promising step forward in the detection and monitoring of colorectal cancer.

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Tumor-derived exosomes in colorectal cancer progression and their clinical applications

Cited by 53 publications

References 82 publications

Extracellular Vesicles in Cancer

Extracellular Vesicles in Cancer

The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications

The importance of circulating tumor products as „liquid biopsies” in colorectal cancer

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