Tumor-derived extracellular vesicles containing long noncoding RNA PART1 exert oncogenic effect in hepatocellular carcinoma by polarizing macrophages into M2

Zhou, Jingyang; Che, Jinhui; Yang, Wei‐Cai; Zhou, Wuyuan; Zhou, Cuncai

doi:10.1016/j.dld.2021.07.005

Cited by 24 publications

(11 citation statements)

References 29 publications

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“…Among the identified HP‐hDEmiRs, has‐miR‐30a‐5p (overexpressed) and has‐miR‐372‐3p (downregulated) are known to interact with 150 and 198 high‐confidence targets, respectively. The has‐miR‐30a‐5p is a potential biomarker and therapeutic target in multiple cancers, 39 while has‐miR‐372‐3p is also associated with Wnt signaling pathway to promote epithelial‐mesenchymal transition 40,41 . Among the high‐confidence targets, MBNL1 and NUFIP2 were targeted by 13 and 11 HP‐hDEmiRs, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Helicobacter pylori regulated microRNA map of human gastric cells

et al. 2022

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Helicobacter pylori (H. pylori) is a gram-negative, spiral bacterium that colonizes human stomach. Specially, this infection is associated with peptic ulcers and gastric cancers world-wide. [1][2][3] It is also classified as class 1 carcinogen for gastric cancer. 4 Due to the rapid identification of newer strains of this pathogenic bacteria, significant increase in the knowledge of its infectivity and pathogenicity has been conferred in past few decades. In the acidic environment of the stomach, this bacterium survives through an array of

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Section: Discussionmentioning

confidence: 99%

“…therapeutic target in multiple cancers, 39 while has-miR-372-3p is also associated with Wnt signaling pathway to promote epithelialmesenchymal transition. 40,41 Among the high-confidence targets, MBNL1 and NUFIP2 were targeted by 13 and 11 HP-hDEmiRs, respectively. Both of these genes play a crucial role in RNA metabolism.…”

Section: F I G U R Ementioning

confidence: 99%

Helicobacter pylori regulated microRNA map of human gastric cells

et al. 2022

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“…15 It is also reported that lncRNA PART1 is transferred from HCC cells to surrounding macrophages via HCC cell-derived extracellular vesicles (EVs) that triggers macrophage polarization toward the M2 subtype by targeting miR-372-3p/TLR4 axis. 16 Similarly, TUC339, a lncRNA enriched in HCC-secreted exosomes, is transmitted from HCC cells to peri-tumor macrophages and greatly affects macrophage polarization and activity. Overexpression of TUC339 in human macrophage cell lines THP-1 contributes to M2 phenotype, polarization, and decreased phagocytic activity, decreased pro-inflammatory cytokine (IL1β and TNF-α) production, reduced costimulatory molecule expression, and augmented viability of macrophages, therefore diminishing the antitumor immune response against tumor cells.…”

Section: Ncrnas and Macrophagesmentioning

confidence: 99%

Role of Noncoding RNAs in the Tumor Immune Microenvironment of Hepatocellular Carcinoma

Lv¹,

Wang²,

Yuan³

2023

J Clin Transl Hepatol

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“…Many studies have revealed the mechanism of action of lncRNAs in TAM polarization regulation. Overexpression of PART1 promotes macrophage M2-like polarization by affecting the miR-372-3p/TLR4 axis ( 74 ). Similarly, promoting competitive adsorption of miR-147a by lncRNA HMMR-AS1 in a hypoxic environment affected ARID3A-mediated macrophage polarization ( 75 ).…”

Section: Regulatory Mechanisms Of Ncrnas In Hccmentioning

confidence: 99%

Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential

et al. 2022

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Hepatocellular carcinoma (HCC) is a complex and heterogeneous malignancy with high incidence and poor prognosis. In addition, owing to the lack of diagnostic and prognostic markers, current multimodal treatment options fail to achieve satisfactory outcomes. Tumor immune microenvironment (TIME), angiogenesis, epithelial-mesenchymal transition (EMT), invasion, metastasis, metabolism, and drug resistance are important factors influencing tumor development and therapy. The intercellular communication of these important processes is mediated by a variety of bioactive molecules to regulate pathophysiological processes in recipient cells. Among these bioactive molecules, non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), account for a large part of the human transcriptome, and their dysregulation affects the progression of HCC. The purpose of this review is to evaluate the potential regulatory mechanisms of ncRNAs in HCC, summarize novel biomarkers from somatic fluids (plasma/serum/urine), and explore the potential of some small-molecule modulators as drugs. Thus, through this review, we aim to contribute to a deeper understanding of the regulatory mechanisms, early diagnosis, prognosis, and precise treatment of HCC.

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Tumor-derived extracellular vesicles containing long noncoding RNA PART1 exert oncogenic effect in hepatocellular carcinoma by polarizing macrophages into M2

Cited by 24 publications

References 29 publications

Helicobacter pylori regulated microRNA map of human gastric cells

Helicobacter pylori regulated microRNA map of human gastric cells

Role of Noncoding RNAs in the Tumor Immune Microenvironment of Hepatocellular Carcinoma

Non-coding RNAs in hepatocellular carcinoma: Insights into regulatory mechanisms, clinical significance, and therapeutic potential

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