Tumor inhibitors. LXXXX. Steganacin and steganangin, novel antileukemic lignan lactones from Steganotaenia araliacea

Anticancer activity of flavonol and flavan-3-ol rich extracts fromCroton celtidifoliuslatex

“…A novel benzofuran lignin that is a derivative of the naturally occurring active principles of Sangue-de-Dragão látex Benfur was identified as a potential antiproliferative and antitumor agent that caused G2/M cell cycle arrest in tumor cells via the p53 pathway. The lignans steganacin and steganangin also showed antitumor activity in murine models of leukemia, and in human nasopharyngeal carcinomas (Kupchan et al, 1973). Other studies have also shown that some lignans cause DNA fragmentation in HeLa leukemic cells in vitro (Chen et al, 2005).…”

Qualitative and quantitative biological analysis of leaves of Sesbania grandiflora

“…Soaked was filtered and the filtrate was condensed by a vacuum revolving evaporator at 40 °C . Concentrated aqueous ethanolic extractive was fractionated by the method of Kupchan et al [5]. Obtained fractions were ethyl acetate soluble (EASF), pet.…”

The Application of Molecular Tethers in Controlling Axial Chirality

“…[6][7][8] For example, the dibenzocyclooctadiene steganacin (1) was found to be an especially potent antitumor agent with significant in vivo activity against P388 leukaemia cells and in vitro activity against human throat cancer cells (Figure 2). [9] A key structural feature of steganacin is its axial chirality. The structure-activity relationship of steganacin was investigated by Tomioka et al who concluded that one of the requirements for high bioactivity is an aR configuration around the axial linkage.…”