Tumor microenvironment and nanotherapeutics: intruding the tumor fort

Kiran, Ammu V. V. V. Ravi; Kumari, Garikapati Kusuma; Krishnamurthy, Praveen Thaggikuppe; Khaydarov, Renat R.

doi:10.1039/d1bm01127h

Cited by 40 publications

(29 citation statements)

References 284 publications

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Section: Resultsmentioning

confidence: 99%

“…The maximal fluorescence signal was observed at 6 h post injection, and considerable enrichment at the tumour sites could remain for 10 h. These results suggested that NP-DNs could specifically accumulate in tumours, possibly due to the enhanced permeation and retention (EPR) effect. 52,53 The antitumor efficacy of NP-DNs was then determined in tumour-bearing nude mice. The mice were randomly assigned to 3 groups (n = 5) and intravenously injected with PBS, NP-DNs (10 mg kg −1 ), or NP-DNs (10 mg kg −1 ) with Fer-1 (1 mg kg −1 ).…”

Section: Biomaterials Science Papermentioning

confidence: 99%

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A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Biomaterials Science Papermentioning

confidence: 99%

A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy

et al. 2022

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“…Recently, stimuli-responsive nanoparticles have also been proposed as a promising active targeting strategy for tumor treatment [ 18 – 22 ]. Specifically, an acidic environment, high levels of reactive oxygen species (ROS) and glutathione (GSH), and overexpression of specific enzymes in the tumor microenvironment (TME) can contribute to the development of stimuli-responsive nanoparticles for targeted drug delivery, as these nanoparticles maintain their stealth features in the normal physiological environment but upon homing to targeted sites or the local microenvironment are responsive and release encapsulated agents [ 18 – 21 ]. Moreover, functionalized nanoparticles can also be activated by external stimuli including magnetic fields, light, and ultrasound, to realize efficient tumor accumulation and controlled drug release in a temporal and spatial-specific fashion [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

et al. 2022

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Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving the therapeutic potential of various agents and bioactive molecules through the enhanced permeability and retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective delivery to the tumor cells utilizing cell surface-specific receptors, the tumor vasculature and antigens with high accuracy and affinity. Additionally, stimuli-responsive nanoplatforms have also been considered as a promising and effective targeting strategy against tumors, as these nanoplatforms maintain their stealth feature under normal conditions, but upon homing in on cancerous lesions or their microenvironment, are responsive and release their cargoes. In this review, we comprehensively summarize the field of active targeting drug delivery systems and a number of stimuli-responsive release studies in the context of emerging nanoplatform development, and also discuss how this knowledge can contribute to further improvements in clinical practice.

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“…Nanodrugs can specifically aggregate at the tumor site due to the enhanced permeability and retention (EPR) effect, [ 8 ] and through appropriate modifications, nanoparticles (NPs) can achieve active targeting to tumors. Moreover, nanodrugs can result in sustained release and circulation in blood, reducing toxicity and side effects and can also maintain the integrity and biological activity of the drug.…”

Section: Introductionmentioning

confidence: 99%

Reactive Oxygen Species‐Mediated Pyroptosis with the Help of Nanotechnology: Prospects for Cancer Therapy

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et al. 2022

Advanced NanoBiomed Research

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Pyroptosis is a recently discovered programmed cell death mechanism, characterized by continuous swelling of cells until the rupture of the cell membrane, resulting in the release of cell contents. [1] Pyroptosis is widely involved in the occurrence and development of infectious and inflammatory diseases and plays an important role in tumor therapy. Specific induction of tumor pyroptosis has achieved great success in tumor therapy. An in-depth study of cell pyroptosis is helpful for stimulating novel ideas for the treatment of tumors. In recent years, research focusing on pyroptosis has increased rapidly, making it a hot research topic.Classic pyroptosis is achieved by activating the gasdermin family of proteins. In the 1990s, pyroptosis was first described in macrophages infected with Salmonella typhimurium. At first, pyroptosis was thought to be mediated by the inflammasome, but it has been shown that pyroptosis is mediated by the gasdermin family of effector proteins promoting pore formation. [2] Caspase-1 and caspase-11/4/5 induce pyroptosis by cleaving gasdermin-D (GSDMD). After being cleaved by caspase-1 or caspase-11/4/5, GSDMD releases its N-terminal domain, which forms a pore on the cell membrane, leading to a change in the osmotic pressure of the cell and swelling until the final rupture of the cell. [3] With further research, other proteins of the gasdermin family, such as gasdermin-A3, (GSDMA3) gasdermin-C (GSDMC), and gasdermin-E (GSDME), have also been shown to be capable of inducing pyroptosis. [4]

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Tumor microenvironment and nanotherapeutics: intruding the tumor fort

Abstract: The tumor microenvironment is an obstructive fort that hinders the delivery of drugs. Manipulating this fort using nanoparticle-based strategies could aid in effectively managing tumors.

Cited by 40 publications

References 284 publications

A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy

A glutathione-responsive sulfur dioxide polymer prodrug selectively induces ferroptosis in gastric cancer therapy

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Reactive Oxygen Species‐Mediated Pyroptosis with the Help of Nanotechnology: Prospects for Cancer Therapy

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