Tumor necrosis factor in the pathogenesis of infectious diseases

Beutler, Bruce; Grau, Georges E.

doi:10.1097/00003246-199310001-00003

Cited by 213 publications

(132 citation statements)

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“…Platelets may also have proapoptotic effects on TNF-activated human brain microvascular endothelial cells (HBEC-5i) 4 in vitro (25). Inflammatory mediators such as TNF are key to the pathogenesis of infectious diseases (5), and fatal CM is associated with high circulating levels of this cytokine (6,7), although other inflammatory mediators are also involved (8). Besides its well-documented effects on up-regulation of endothelial adhesion molecules, it is also evident that TNF in vitro acts as a potent inducer of endothelial cell apoptosis (9).…”

Section: Tgf-␤ 1 Released From Activated Platelets Can Inducementioning

confidence: 99%

TGF-β1 Released from Activated Platelets Can Induce TNF-Stimulated Human Brain Endothelium Apoptosis: A New Mechanism for Microvascular Lesion during Cerebral Malaria

Wassmer

Souza

Frère

et al. 2006

The Journal of Immunology

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Platelets have recently been shown to accumulate in brain microvessels of patients with cerebral malaria and to modulate the binding of Plasmodium falciparum-infected red cells to human brain endothelium in vitro. In the present study we used a platelet-endothelial cell coculture model to investigate the mechanisms by which platelets modify the function of human brain microvascular endothelial cells (HBEC). Platelets were found to have a proapoptotic effect on TNF-activated HBEC, and this was contact-dependent, as inhibiting platelet binding prevented endothelial cell killing. We also showed that the supernatants of thrombin-activated platelets killed TNF-stimulated HBEC and that TGF-β1 was the main molecule involved in endothelial cell death, because its inhibition completely abrogated the activated-platelet supernatant effect. Our data illustrate another aspect of the duality of TGF-β1 in malaria and may provide new insights into the pathogenesis of cerebral malaria.

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Section: Tgf-␤ 1 Released From Activated Platelets Can Inducementioning

confidence: 99%

TGF-β1 Released from Activated Platelets Can Induce TNF-Stimulated Human Brain Endothelium Apoptosis: A New Mechanism for Microvascular Lesion during Cerebral Malaria

Wassmer

Souza

Frère

et al. 2006

The Journal of Immunology

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“…Уровень продукции TNFα значительно воз-растает при поступлении бактериальных эндо-токсинов в организм человека. Ряд авторов в своих исследованиях, с использованием ней-трализующих действие фактора некроза антите-лами, подтвердили центральную роль цитокина в возникновении токсического шока и сепси-са [11,13,14].…”

Section: Discussionunclassified

“…Данный цитокин может высту-пать в роли медиатора защитной реакции в от-вет на различные инфекционные агенты, а также в качестве белка, обладающего пагубным влия-нием на организм [9,11,13,14].…”

Section: Snp Tnfα и уровень Tnfα при роже Tnfα Snp and Tnfα Level On unclassified

PROMOTER REGION rs1800629 TNFα POLYMORPHISM AND ITS INFLUENCE ON TUMOR NECROSIS FACTOR ALPHA CONCENTRATION IN BLOOD OF HEALTHY INDIVIDUALS AND PATIENTS WITH ERYSIPELAS

Емельянов¹,

Емельянова²,

Pushkarev³

et al. 2018

Med. immunol.

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“…TNF-α is a critical cytokine in the inflammatory response to infection. 27 Accordingly, any genetic variability in the production of TNF-α after an infectious stimulus could significantly affect the degree of the inflammatory response and the clinical outcome. 28 To our knowledge, there are no reports of measurements of TNF-α levels around miniscrews used as an anchorage unit in orthodontics.…”

Section: Discussionmentioning

confidence: 99%

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

et al. 2011

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Objective: The aim of this study was to measure tumor necrosis factor-α (TNF-α) levels around miniscrews used for anchorage during a 3-month period of canine distalization. Methods: Sixteen patients (8 boys, 8 girls; mean age, 16.6 ± 2.4 years) whose upper first premolars were extracted for orthodontic treatment were included in this study. Miniscrews were used as an anchorage unit in canine distalization. Thirty-two (32) miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars. The treatment, miniscrew, and control groups comprised upper canines, miniscrew implants, and upper first premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid were obtained before applying force and at 1, 24, and 48 hours, and at 7 and 21 days, and 3 months after applying force. Results: During the 3-month period, the TNF-α levels increased significantly at 24 hours only in the treatment group (p ＜ 0.01). In the miniscrew and control groups, there were no statistically significant changes. No significant differences were observed between groups. Conclusions: Miniscrews can be conveniently used for anchorage in orthodontics.

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Tumor necrosis factor in the pathogenesis of infectious diseases

Cited by 213 publications

References 0 publications

TGF-β1 Released from Activated Platelets Can Induce TNF-Stimulated Human Brain Endothelium Apoptosis: A New Mechanism for Microvascular Lesion during Cerebral Malaria

TGF-β1 Released from Activated Platelets Can Induce TNF-Stimulated Human Brain Endothelium Apoptosis: A New Mechanism for Microvascular Lesion during Cerebral Malaria

PROMOTER REGION rs1800629 TNFα POLYMORPHISM AND ITS INFLUENCE ON TUMOR NECROSIS FACTOR ALPHA CONCENTRATION IN BLOOD OF HEALTHY INDIVIDUALS AND PATIENTS WITH ERYSIPELAS

Identification of tumor necrosis factor-α levels around miniscrews during canine distalization

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