Tumor necrosis factor‐α inhibitors alleviation of experimentally induced neuropathic pain is associated with modulation of TNF receptor expression

Andrade, Pablo; Hoogland, Govert; Rosario, Del; Steinbusch, Harry W.M.; Visser‐Vandewalle, Veerle; Daemen, M.A.R.C.

doi:10.1002/jnr.23432

Cited by 36 publications

(26 citation statements)

References 47 publications

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“…TNF-a protein has been reported to correspond with decreased pain thresholds [38]. In agreement, it is found that anti-TNF-a treatment resulted in a significant alleviation of pain in a rat CCI model [39], consistently a study showed antimechanical allodynia effect of a compound in rat CCI model, and it was related to decrease in TNF-a expression in the sciatic nerve [40].…”

Section: Discussionmentioning

confidence: 61%

Effect of ursolic acid in attenuating chronic constriction injury‐induced neuropathic pain in rats

Bhat

Lingaraju

Pathak

et al. 2016

Fundamemntal Clinical Pharma

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Ursolic acid (UA; 3b-hydroxy-12-urs-12-en-28-oic acid), a natural pentacyclic triterpenoid carboxylic acid, has been known to possess potent anti-inflammatory, antioxidant, and antinociceptive effects in various animal models. Therefore, this study was designed to investigate the antihyperalgesic, anti-inflammatory, and antioxidant effects of UA at 5, 10, and 20 mg/kg of doses via per os (p.o.) route for 14 days in chronic constriction injury (CCI)-induced neuropathic pain in rats. Pain behavior in rats was evaluated before and after UA administration via mechanical and heat hyperalgesia. CCI caused significant increase in levels of pro-inflammatory cytokines and oxido-nitrosative stress. In addition, significant increase in myeloperoxidase, malondialdehyde, protein carbonyl, nitric oxide (NO), and total oxidant status (TOS) levels in sciatic nerve and spinal cord concomitant with mechanical and heat hyperalgesia is also noted for CCI-induced neuropathic pain. Administration of UA significantly reduced the increased levels of pro-inflammatory cytokines and TOS. Further, reduced glutathione is also restored by UA. UA also showed in vitro NO and superoxide radical scavenging activity. UA has a potential in attenuating neuropathic pain behavior in CCI model which may possibly be attributed to its anti-inflammatory and antioxidant properties.

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Section: Discussionmentioning

confidence: 61%

Effect of ursolic acid in attenuating chronic constriction injury‐induced neuropathic pain in rats

Bhat

Lingaraju

Pathak

et al. 2016

Fundamemntal Clinical Pharma

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“…34 TNF and IL-1 have also been shown to modulate pain perception. 35,36 Doong et al demonstrated that variations in pro- and anti-inflammatory genes are associated with pain, fatigue, sleep disturbance, and depression in patients with breast cancer. 5 These inflammatory cytokines are known to be up regulated in CRS.…”

Section: Discussionmentioning

confidence: 99%

The pain–depression dyad and the association with sleep dysfunction in chronic rhinosinusitis

Cox

Ashby

Mace

et al. 2016

Int Forum Allergy Rhinol

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Background Depression, pain, and sleep disturbance is a symptom cluster often found in patients suffering from chronic illness, exerting a large impact on quality-of-life (QOL). A wealth of literature exists demonstrating a significant association between depression, pain, and sleep dysfunction in other chronic diseases. This relationship has not been described in patients with chronic rhinosinusitis (CRS). Methods Sixty-eight adult patients with CRS were prospectively enrolled. Patients at risk for depression were identified using the Patient Health Questionnaire-2 (PHQ-2) using a cutoff of 1 or greater. Pain experience was measured using the Brief Pain Inventory Short Form (BPI-SF) and the Short Form McGill Pain Questionnaire (SF-MPQ). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Results Forty-seven patients were at risk for depression. Significant positive correlations were found between total PSQI scores and all pain measures (R=0.38–0.61, p≤0.05) and between total PSQI scores and PHQ-2 scores (R=0.46, p<0.05). For patients at risk for depression, significant, positive correlations were found between pain measures, the total PSQI score, and the three PSQI subdomains (sleep latency, sleep quality, and daytime dysfunction; R=0.31-0.61, p<0.05). The relationship between pain and sleep dysfunction scores was not seen in the absence of depression. Conclusions Depression, pain, and sleep dysfunction are inter-related in patients with CRS. In the absence of depression significant correlations between pain and sleep are not observed, suggesting that depression plays a key role in this interaction. Further research investigating the complex relationship between depression, pain, and sleep dysfunction in CRS is needed.

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“…TNF-α influences neural survival, exerting both neuroprotective and neurodegenerative actions [13]. Following peripheral nerve injury, upregulation of TNF-α expression has been documented in several neuropathic pain models [14]. In contrast, anti-inflammatory cytokines, such as interleukin 4 (IL-4), may inhibit pro-inflammatory cytokine response.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of the Inflammatory Cytokines in Patients with Lumbar Radicular Pain Due to Disc Herniation

Pan

Zhang

et al. 2016

Asian Spine J

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Study DesignCohort study.PurposeThis study primarily aimed to evaluate the serum levels of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-4 in patients with lumbar radiculopathy 1 and 12 months after microdiscectomy.Overview of LiteratureLumbar radiculopathy is possibly caused by inflammatory changes in the nerve root. The intraneural application of pro-inflammatory cytokines induces behavioral signs associated with pain. Anti-inflammatory cytokine treatment effectively reduces hyperalgesia.MethodsThe role of TNF-α and IL-4 in long-lasting lumbar radiculopathy was addressed. A total of 262 patients were recruited from Anqing Hospital, Anhui Medical University. During inclusion at 1 and 12 months, serum concentrations of TNF-α and IL-4 were analyzed by enzyme-linked immunosorbent assay, and pain intensity was reported on a 0–10 cm visual analog scale (VAS).ResultsSixty six patients had VAS <3 and 196 patients had VAS ≥3. Serum concentrations of pro-inflammatory TNF-α and anti-inflammatory IL-4 in patients with lumbar radiculopathy related to disc herniation were measured at 1- and 12-month follow-up. TNF-α decreased in both VAS groups with time. In contrast, IL-4 increased in both groups at 1 month and then decreased gradually until month 12. The changes in serum levels of TNF-α and IL-4 over time between the VAS ≥3 and VAS <3 groups were significantly different.ConclusionsChronic lumbar radiculopathy may be associated with high level of pro-inflammatory substances, such as TNF-α, in serum after disc herniation, and elevated anti-inflammatory cytokine in patients with lumbar radiculopathy may indicate a favorable outcome.

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Tumor necrosis factor‐α inhibitors alleviation of experimentally induced neuropathic pain is associated with modulation of TNF receptor expression

Cited by 36 publications

References 47 publications

Effect of ursolic acid in attenuating chronic constriction injury‐induced neuropathic pain in rats

Effect of ursolic acid in attenuating chronic constriction injury‐induced neuropathic pain in rats

The pain–depression dyad and the association with sleep dysfunction in chronic rhinosinusitis

Serum Levels of the Inflammatory Cytokines in Patients with Lumbar Radicular Pain Due to Disc Herniation

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