Tumor-self-targeted “thermoferroptosis-sensitization” magnetic nanodroplets for multimodal imaging-guided tumor-specific therapy

Wang, Junrui; Song, Weixiang; Wang, Xingyue; Xie, Zhuoyan; Zhang, Wenli; Jiang, Weixi; Liu, Shilin; Hou, Jingxin; Zhong, Yixin; Xu, Jie; Ran, Haitao; Guo, Dajing

doi:10.1016/j.biomaterials.2021.121100

Cited by 15 publications

(9 citation statements)

References 47 publications

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“…The SPIO-NPs are exploited as T 2 agents, but due to their larger size (10-100 nm) and strong magnetic moment can create exaggerated MRI contrast, thereby affecting the localization of the NPs in the tissue. 54 The T 2 -based SPIO-NPs are commercially available e.g. Feridex, Resovist, and Supravist.…”

Section: Discussionmentioning

confidence: 99%

Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography

et al. 2022

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“…Most nanomedicines are limited by their delivery efficiency to the tumor site and deep penetration. The mild-temperature magnetic fluid hyperthermia was proposed to tackle these problems, which induces ferroptosis by up-regulating ACSL4 protein and depleting GSH as well as producing the thermoferroptosis sensitization to overcome the current impediments in cancer nanomedicine . An “all-in-one nanosoldier” strategy that integrates ferroptosis with the magneto-hyperthermia effect and targeted membrane receptors was reported for fighting the metastasis and resistance of triple-negative breast cancer (TNBC) .…”

Section: Ferroptosis Nanotherapeutics Combined With Other Therapeutic...mentioning

confidence: 99%

“…The mild-temperature magnetic fluid hyperthermia was proposed to tackle these problems, which induces ferroptosis by up-regulating ACSL4 protein and depleting GSH as well as producing the thermoferroptosis sensitization to overcome the current impediments in cancer nanomedicine. 293 An "all-inone nanosoldier" strategy that integrates ferroptosis with the magneto-hyperthermia effect and targeted membrane receptors was reported for fighting the metastasis and resistance of triplenegative breast cancer (TNBC). 294 The colloidal nanohybrid nanostructures are simultaneously integrated with targeting, imaging, and killing features against TNBC cells.…”

Section: Ferroptosis Nanotherapeutics Combinedmentioning

confidence: 99%

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Zhu

Meng

Wang

et al. 2022

ACS Appl. Bio Mater.

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Ferroptosis, characterized by iron-dependent lipid reactive oxygen species (ROS) accumulation, is non-apoptotic programmed cell death highly relevant to tumor development. It was found to manipulate oncogenes and resistant mutations of cancer cells via lipid metabolism pathways converging on phospholipid glutathione peroxidase (GPX4) that squanders lipid peroxides (L-OOH) to block the iron-mediated reactions of peroxides, thus rendering resistant cancer cells vulnerable to ferroptotic cell death. By accumulating ROS and lipid peroxidation (LPO) products to lethal levels in tumor microenvironment (TME), ferroptosis-driven nanotherapeutics show a superior ability of eradicating aggressive malignancies than traditional therapeutic modalities, especially for the drug-resistant tumors with high metastasis tendency. Moreover, Fenton reaction, inhibition of GPX-4, and exogenous regulation of LPO are three major therapeutic strategies to induce ferroptosis in cancer cells, which were generally applied in ferroptosis-driven nanotherapeutics. In this review, we elaborate current trends of ferroptosisdriven nanotherapeutics to reverse drug resistance of tumors in anticancer fields at the intersection of cancer biology, materials science, and chemistry. Finally, their challenges and perspectives toward feasible translational studies are spotlighted, which would ignite the hope of anti-resistant cancer treatment.

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“…Simultaneously, liquid fluorocarbon phase change can enhance the ultrasound imaging function. These two are combined to achieve dual-modality imaging using ultrasound and photoacoustics [ [22] , [23] , [24] ].…”

Section: Introductionmentioning

confidence: 99%

Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma

Shi¹,

Li²,

Zheng³

et al. 2022

Materials Today Bio

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Tumor-self-targeted “thermoferroptosis-sensitization” magnetic nanodroplets for multimodal imaging-guided tumor-specific therapy

Cited by 15 publications

References 47 publications

Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography

Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography

Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment

Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma

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