Tumor size as a prognostic factor for patients with colon cancer undergoing sentinel lymph node mapping and conventional surgery.

Abstract

546 Background: Unlike other solid tumors, tumor size (TS) is not a part of the TNM staging for colon cancer (CC). Our goal is to correlate TS with TNM staging, nodal positivity(NP), and 5-year overall survival (OS) for patients (pts) with invasive CC undergoing sentinel lymph node mapping (SLNM) vs. conventional surgery (CS). Methods: A retrospective review of 681 pts with invasive CC were reviewed and divided into two groups of pts (SLNM and CS). The pts in these two groups were subdivided according to the TS in four groups (0-2, 2-4, 4-6 and more than 6 cm). 461 pts underwent SLNM between 1996-2010 compared to 220 pts who underwent CS between 1996-2006. The pathology reports reviewed for TS (the maximum diameter of the primary tumor), T staging, and NP. The OS was calculated from the social security database and our hospital cancer registry. Then all data was compared between both groups. Results: Pts with TS <2cm were mainly T1+T2 (72%, 70%), whereas tumors >6 cm, majority of pts wereT3+T4 (94%, 85%). T1+T2 percentage consistently decreased as TS increased, and T3+T4 percentage was increasing consistently with increased TS (Table 1A). NP according to TS for SLNM pts were (16%, 53%, 56%, 48%) NP and for CS pts were (15%, 32%, 34%, 39%). In both groups, NP increased as TS increased compared to 0-2 cm group. The overall NP in both groups was 47% and 31% (Table 1B). OS for SLNM and CS pts were calculated in each group according to TS. Overall SLNM pts had better OS when compared to CS pts (65 %, 54%). Conclusions: Increasing TS was consistent with increasing T staging for both SLNM and CS pts. NP and OS were worse with increased TS for SLNM and CS pts. SLNM pts had higher NP and better outcome in OS when compared to CS pts, hence TS should be considered as a prognostic factor in pts with adenocarcinoma of the colon. [Table: see text]

Primary Tumor Size as a Predictor of Prognosis in Patients with Stage IV Colorectal Cancer: Population analysis based on two centers

“…Our study is supported by several previous studies (10)(11)(12)21). Saha et al (11) examined the role of tumor size in a large retrospective analysis of 300,386 patients and reported that tumor size was positively associated with important prognostic factors (such as T stage and N stage) and had negative impact on survival.…”

“…Theoretically, tumor size ought to serve as a key predictor of treatment response and prognosis. While tumor size has been shown to have prognostic value in stage II and III CRC (10)(11)(12), its value in stage IV CRC is not yet established.…”

The Role of IL-37 and IL-38 in Colorectal Cancer

“…Notably, right-sided CRC is frequently diagnosed at a later stage, with the tumor size being larger, due to the capacious nature of the proximal colon (47). It is well known that the tumor size and depth of invasion (58) correlates with prognosis and overall survival rate of primary CRC patients (59).…”

P–TNM staging system for colon cancer: combination of P-stage and AJCC TNM staging system for improving prognostic prediction and clinical management

“…Previous studies showed that age at diagnosis, 3 , 6 – 9 tumor grade, 4 , 10 , 11 and tumor size 5 , 12 , 13 had a strong correlation with the prognosis of colon cancer. For example, Saha et al 13 found that the 5-year overall survival was 66%, 52%, 46%, and 41% in the subgroups with tumor sizes of 0–2, >2–4, >4–6, and >6 cm, respectively.…”

“…Moreover, many subsequent studies revealed that age at diagnosis, 6 – 9 tumor grade, 10 , 11 and tumor size 12 , 13 had a strong correlation with the prognosis of colon cancer. Yet most of them focus on the prognostic significance of one single factor and no study attempt to combine the three factors together for improved prognostic prediction.…”