Tumorous-head-type mutants of the distal bithorax complex cause dominant gain and recessive loss of function in Drosophila melanogaster

Kuhn, David T.; Packert, Gerhild

doi:10.1016/0012-1606(88)90054-1

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…Similar dominant mutations have been described in the BX-C. For instance, Ubx is required to specify the meta-thoracic (T3), but not the mesothoracic (T2) segment, and Ubx gain-of-function mutations partially transform the latter into the former, including transformation of wings (dorsal mesothoracic appendages) into halteres (dorsal metathoracic ones; Lewis, 1978;Cabrera et al, 1985;White and Akam, 1985). Gain-of-function mutations in abd-A and Abd-B also transform different segments into more posterior ones (Gardner, 1970;Lewis, 1978;Karch et al, 1985;Celniker and Lewis, 1987;Kuhn and Packert, 1988;Busturia et al, 1989;Crosby et al, 1993). However, all of these transformations are frequently incomplete, and sometimes vary significantly in penetrance and expressivity.…”

Section: Introductionmentioning

confidence: 99%

Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes.

1996

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In Drosophila, the Ultrabithorax, abdominal‐A and Abdominal‐B HOX genes of the bithorax complex determine the identity of part of the thorax and the whole abdomen. Either the absence of these genes or their ectopic expression transform segments into the identity of different ones along the antero‐posterior axis. Here we show that misexpression of Ultrabithorax, abdominal‐A and, to some extent, Abdominal‐B genes cause similar transformations in some of the fruitfly appendages: antennal tissue into leg tissue and wing tissue into haltere tissue. abdominal‐A can fully, and Abdominal‐B partially, substitute for Ultrabithorax in haltere development. By contrast, when ectopically expressed, the three genes specify different segments in regions of the main body axis like notum or abdomen. Insects may have originally used the HOX genes primarily to specify this main body axis. By contrast, the homeotic requirement to form appendages is, in some cases, non‐specific.

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Section: Introductionmentioning

confidence: 99%

Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes.

1996

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Direct control of antennal identity by the spineless-aristapedia gene of Drosophila

Burgess

Duncan

1990

Mol Gen Genet

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Loss-of-function mutations in the spineless-aristapedia gene of Drosophila (ssa mutants) cause transformations of the distal antenna to distal second leg, deletions or fusions of the tarsi from all three legs, a general reduction in bristle size, and sterility. Because ssa mutants are pleiotropic, it has been suggested that ss+ has some rather general function and that the ssa antennal transformation is an indirect consequence of perturbations in the expression of other genes that more directly control antennal or second leg identity. Here we test whether the ssa transformation results from aberrant expression of Antennapedia (Antp), a homeotic gene thought to specify directly the identity of the second thoracic segment. We find that Antp-ssa mitotic recombination clones in the distal antenna behave identically to Antp+ ssa clones, and are transformed to second leg. This demonstrates that the ssa antennal transformation is independent of Antp+, and suggests that ss+ may itself directly define distal antennal identity. The results also reveal that Antp+ is not required for the development of distal second leg structures, as these develop apparently normally in Antp- ssa antennal clones. Because Antp- mutations cause deletions or transformations that are restricted to proximal structures, whereas ssa alleles cause similar defects that are distally restricted, we suggest that ss+ and Antp+ may play similar, but complementary, roles in the distal and proximal portions of appendages, respectively.

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The Ultrabithorax gene of Drosophila and the specification of abdominal histoblasts

Frayne

Sato

1991

Developmental Biology

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Tumorous-head-type mutants of the distal bithorax complex cause dominant gain and recessive loss of function in Drosophila melanogaster

Cited by 8 publications

References 21 publications

Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes.

Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes.

Direct control of antennal identity by the spineless-aristapedia gene of Drosophila

The Ultrabithorax gene of Drosophila and the specification of abdominal histoblasts

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