2020
DOI: 10.1073/pnas.1916562117
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Tunable and precise miniature lithium heater for point-of-care applications

Abstract: Point-of-care diagnostic assays often involve multistep reactions, requiring a wide range of precise temperatures. Although precise heating is critical to performing these assays, it is challenging to provide it in an electricity-free format away from established infrastructure. Chemical heaters are electricity-free and use exothermic reactions. However, they are unsuitable for point-of-care multistep reactions because they sacrifice portability, have a narrow range of achievable temperatures, and long ramp-up… Show more

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Cited by 7 publications
(5 citation statements)
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“…Our assay has the advantage of ELISA-like analytical sensitivities but is portable and can be used at point-of-care. All reagents can be placed in a tablet for easy transport and utility …”
Section: Resultsmentioning
confidence: 99%
“…Our assay has the advantage of ELISA-like analytical sensitivities but is portable and can be used at point-of-care. All reagents can be placed in a tablet for easy transport and utility …”
Section: Resultsmentioning
confidence: 99%
“…Isothermal NAATs often run best at temperature at about 30–65 ​°C, which require a constant temperature heating unit, limiting their implementation to locations with dedicated electricity. Temperatures in this range can be maintained for the required time using chemical and battery-operated electrical heaters ( Roskos et al., 2013 ; Shah et al., 2015 ; Udugama et al., 2020 ). Alternatively, enzymes can be developed or isolated (e.g., from cold water organisms) that maintain reaction efficiency at lower temperatures making heating less or not necessary.…”
Section: Discussionmentioning
confidence: 99%
“…We estimate the cost of the tablet to be $0.13 USD (Table S2), so it may be an affordable solution for a broad range of analytical applications. The portability of multilayered tablet diagnostic assays can be further supported by the use of portable detectors such as smartphone cameras. , Finally, we can add a heating element using lithium tablets alongside multilayered tablets . We envision that our methods will be used as a tool to translate multistep assays into tablets, translating many complex assays that can be used at home, in rural areas, and in low-resource settings.…”
Section: Discussionmentioning
confidence: 99%
“…39,46 Finally, we can add a heating element using lithium tablets alongside multilayered tablets. 47 We envision that our methods will be used as a tool to translate multistep assays into tablets, translating many complex assays that can be used at home, in rural areas, and in low-resource settings. Ultimately, we have developed an instrument-free and automated diagnostic tool to simplify multiple-step assays for use by the general public.…”
Section: ■ Conclusionmentioning
confidence: 99%