Tunable porosity of covalently crosslinked alginate-based hydrogels and its significance in drug release behavior

Siboro, Sonita A.P.; Anugrah, Daru Seto Bagus; Ramesh, Kalyan; Park, Sang-Hyug; Kim, Hyeung‐Rak; Lim, Kwon Taek

doi:10.1016/j.carbpol.2021.117779

Cited by 77 publications

(28 citation statements)

References 29 publications

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“…PVA loaded the lowest amount of DFN (14.6 ± 0.9 μg DFN/mg dry sample) and released about 58% of that drug in less than 6 h. This hydrogel has a porous structure with free spaces that can contribute to the fast loading and release of the drug. Other authors [ 61 ] reached similar conclusions regarding the effect of porosity on the drug release from hydrogels. The addition of PAA to PVA led to a notable increase in the amount of drug being loaded and released, which should be related to the presence of hydrophilic carboxylic side groups (–COOH), which was responsible for the extensive swelling and greater porosity.…”

Section: Discussionsupporting

confidence: 72%

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Branco

Oliveira

Monteiro

et al. 2022

Gels

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Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-based hydrogels for this purpose, displaying improved tribomechanical properties with the ability to control the release of diclofenac (DFN). Four types of PVA-based hydrogels were prepared via freeze-thawing: PVA, PVA/PAA (by polyacrylic acid (PAA) addition), PVA/PAA+PEG (by polyethylene glycol (PEG) immersion), and PVA/PAA+PEG+A (by annealing). Their morphology, water uptake, mechanical and rheological properties, wettability, friction coefficient, and drug release behavior were accessed. The irritability of the best-performing material was investigated. The results showed that the PAA addition increased the swelling and drug release amount. PEG immersion led to a more compact structure and significantly improved the material’s tribomechanical performance. The annealing treatment led to the material with the most suitable properties: besides presenting a low friction coefficient, it further enhanced the mechanical properties and ensured a controlled DFN release for at least 3 days. Moreover, it did not reveal irritability potential for biological tissues.

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Section: Discussionsupporting

confidence: 72%

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Branco

Oliveira

Monteiro

et al. 2022

Gels

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“…This result indicates that POMA hydrogels implanted into rabbits do not cause rejection or significant inflammatory reactions and are completely absorbed. The difficulty of degrading alginate-based hydrogels in vivo is a potential obstacle to their application. , Previous studies have found that alginate polymers with high molecular weights are difficult to degrade completely in mammals partly because the high-molecular-weight alginate hydrogels (possessing molecular weight more than 50 kDa) cannot be cleared from the body by the kidneys, and the lack of related hydrolases in vivo that results in the inability to naturally enzymatically degrade the hydrogels under physiological conditions may be another reason. ,, Integrating the in vivo and in vitro degradation results, it was found that the in vivo degradation of the gels was obviously slower than that in vitro, which indicates the necessity of oxidative modification for alginate to accelerate degradation of alginate-based polymers in in vivo applications. In conclusion, the in vivo degradation experiments revealed that although POMA hydrogels degraded more slowly in vivo, the in vivo degradation rate of POMA gels can be tailored by regulating the degree of alginate oxidation, which allows for immense potential to suit the speed of different tissue regeneration, showing great histocompatibility and excellent application prospects in tissue engineering.…”

Section: Results and Discussionmentioning

confidence: 99%

Degradation-Kinetics-Controllable and Tissue-Regeneration-Matchable Photocross-linked Alginate Hydrogels for Bone Repair

Zhao

Wang

Cheng

et al. 2022

ACS Appl. Mater. Interfaces

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Photocross-linked alginate hydrogels, due to their biodegradability, biocompatibility, strong control for gelling kinetics in space and time, and admirable adaptability for in situ polymerization with a minimally invasive approach in surgical procedures, have created great expectations in bone regeneration. However, hydrogels with suitable degradation kinetics that can match the tissue regeneration process have not been designed, which limits their further application in bone tissue engineering. Herein, we finely developed an oxidation strategy for alginate to obtain hydrogels with more suitable degradation rates and comprehensively explored their physical and biological performances in vitro and in vivo to further advance the clinical application for the hydrogels in bone repair. The physical properties of the gels can be tuned via tailoring the degree of alginate oxidation. In particular, in vivo degradation studies showed that the degradation rates of the gels were significantly increased by oxidizing alginate. The activity, proliferation, initial adhesion, and osteogenic differentiation of rat and rabbit bone marrow stromal cells (BMSCs) cultured with/in the hydrogels were explored, and the results demonstrated that the gels possessed excellent biocompatibility and that the encapsulated BMSCs were capable of osteogenic differentiation. Furthermore, in vivo implantation of rabbit BMSC-loaded gels into tibial plateau defects of rabbits demonstrated the feasibility of hydrogels with appropriate degradation rates for bone repair. This study indicated that hydrogels with increasingly controllable and matchable degradation kinetics and satisfactory bioproperties demonstrate great clinical potential in bone tissue engineering and regenerative medicine and could also provide references for drug/growth-factor delivery therapeutic strategies for diseases requiring specific drug/growth-factor durations of action.

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“…The porosity of the wound dressing has a significant effect on the rate of wound healing, as it determines the oxygen permeability and nutrient diffusion capacity directly related to cell proliferation and the wound microenvironment [29]. As shown in Figure 2B, the COS/SA/nM 2+ PDFs all had high a porosity, which enhanced the water retention capacity of gel films and improved the bonding strength inside the gel, which could effectively stabilize the gel structure.…”

Section: Porositymentioning

confidence: 98%

Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing

et al. 2022

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The development of an efficient and convenient material to improve skin tissue regeneration is a major challenge in healthcare. Inspired by the theory of moist wound healing, portable chitooligosaccharide (COS)/sodium alginate (SA) dual-net gel films containing multiple metal ions were prepared by a casting and in -situ spray method, which can be used to significantly promote wound healing without the use of therapeutic drugs. A variety of divalent cations was introduced in this experiment to improve the advantages of each metal ion by forming metal ion chelates with COS. Moreover, the physicochemical properties and antioxidant properties of nIon2+-COS/SA gel films were systematically characterized and evaluated by in vitro experiments. The gel films showed good antibacterial activity against Gram-negative and Gram-positive bacteria. In addition, the gel films showed good cytocompatibility in cellular experiments, and the gel films with Zn2+ and Sr2+ addition significantly accelerated wound healing in whole skin defect model experiments. Therefore, this nIon2+-COS/SA gel film is an ideal candidate material for wound dressing.

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Tunable porosity of covalently crosslinked alginate-based hydrogels and its significance in drug release behavior

Cited by 77 publications

References 29 publications

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement

Degradation-Kinetics-Controllable and Tissue-Regeneration-Matchable Photocross-linked Alginate Hydrogels for Bone Repair

Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing

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