The origin of leather activities in Turkey as a traditional craft goes back to the periods of Seljukian and Ottoman. Mostly performed in Istanbul in early years of the Republic, these activities have also developed in the cities such as İzmir, Gaziantep, Eskişehir, Antakya, Balıkesir, Bursa, Bolu and Denizli after 1950s. Today, looking at the geographical distribution of the leather industry in Turkey, we notice that while a large part of it is located in the Marmara and Aegean regions with powerful transportation utilities and wide marketing opportunities, a smaller part of it is in the regions of Central Anatolia, Mediterranean and Black Sea with poor transportation utilities and marketing opportunities. Various factors such as market, transportation, workforce, capital, energy resources, personal decisions, governmental policies and urbanizations all have played roles in the formation of this pattern of spatial distribution. The objective of this study is to determine geographical distribution of the leather industry activities in Turkey and examine the factors which have been effective in this distribution. A variety of geographical methods and techniques have been used to identify the factors which have been influential in finding location for the leather industry and associated activities.