Turnover of phosphatidylglycerol in Streptococcus sanguis

Excretion of Lipoteichoic Acid by Group A Streptococci

“…Recently it has been demonstrated that exogenous glycerol is incorporated into phosphatidylglycerol in both gram-negative (14) and gram-positive bacteria (2,15). Phosphatidylglycerol has been showin to serve as the precursor of the backbone of LTA (15).…”

The role of phosphatidylglycerol in the in vitro biosynthesis of teichoic acid and lipoteichoic acid

“…(solvent E). Radiolabeled and reference compounds on chromatograms were detected as described previously [4].…”

“…Based on indirect evidence, Anderson et al [2] suggested the involvement of glycosylpolyisoprenylphosphate intermediate in the biosynthesis of teichoic acid. However, the in vivo pulsechase experiments done in our laboratory [3,4] and Glaser's laboratory [5] suggested that phosphatidylglycerol [PG] is the precursor in lipoteichoic acid biosynthesis. In this communication direct evidence is presented to show that PG could serve as donor of the glycerol and phosphate moieties in teichoic acid and lipoteichoic acid biosyntheses.…”

Lipoteichoic Acids, Phosphate-Containing Polymers in the Envelope of Gram-Positive Bacteria

“…It was initially assumed that type I LTA synthesis involves CDP-glycerol; however, in vivo pulse-labeling experiments revealed phosphatidylglycerol (PG) as a precursor for poly-(Gro-P) synthesis (66)(67)(68). Careful characterization of lipid extracts from enterococci suggested that sn-glycerol 1-phosphate (Gro-P)-containing phosphoglycolipids contribute to LTA synthesis (69).…”