The study of the seasonal dynamics of As, Cd, Cr, Cu, Fe, Hg, Ni, Pb, and Zn in the open waters at the water-sediment interface from the lagoon area II of Ébrié system were monitored for a year (from June 2020 to May 2021). In implementation of this study, the water samples were monthly collected near the water-sediment interface from this lagoon area (less than 50 cm) in five sampling sites and, analyzed in accordance to MA 203-Met ICP-MSMS standard. The results were highlighted the relative important of the seasonal trace metals contents of these open waters. All their seasonal trace metals contents were decreased gradually from hot season to flood season. Cr, followed respectively by Cd and Cu were the least abundant; while Ni, followed by As, were the most abundant in these open waters in all seasons over this period.