Two Additional Cases of Coexisting Polycythaemia Vera and Chronic Lymphocytic Leukaemia

Abstract

2 patients with coexistent polycythaemia Vera and chronic lymphocytic leukaemia are described. A 61-year-old man presented with an increased packed cell volume (PCV) and a leucoerythroblastic blood picture, which was reversible upon treatment, neutrophil leucocytosis, bone marrow lymphocyte infiltration and splenomegaly, and subsequently developed lymphomas, blood lymphocytosis and thrombocytosis. The second case was a 58-year-old female presenting with increased PCV and leucocyte alkaline phosphatase score. She later had neutrophil leucocytosis, thrombocytosis, lymphocytosis, lymphomas and splenomegaly. These cases, together with 6 cases published by others, suggest that an association exists between the two diseases.

The coexistence of chronic lymphocytic leukemia and myeloproliperative neoplasms: A retrospective multicentric GIMEMA experience

“…The spectrum of secondary solid neoplasms during the course of CLL includes carcinomas of the skin, stomach, colon, breast, or kidney [4, 5]; among secondary hematologic malignancies, cases of acute lymphocytic, myelocytic, monocytic and myelomonocytic leukemia, erythroleukemia, plasma cell leukaemia [6], and myeloproliferative neoplasms (MPN) have been reported [7–54].…”

“…In fact, most of the reported cases are purely anecdotal and merely descriptive. In a review of the literature, we found 25 cases of CLL/chronic myeloid leukemia (CML) [7–30], 18 cases of CLL/polycythemia vera (PV) [34, 35, 40–53], 12 cases of CLL/essential thrombocythemia (ET) [31–39], and only one case of CLL with primary myelofibrosis (PMF) [54].…”

Simultaneous and Sequential Concurrent Myeloproliferative and Lymphoproliferative Neoplasms

“…Concurrent manifestation of two chronic-phase myeloid and lymphoid neoplasms in one patient is rare and occurs in approximately 1% of patients [11,12]. Several case reports and a few case series have addressed this issue [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91]. Due to its rarity, there has been no systematic evaluation of which combinations of myeloid and lymphoid neoplasms are frequent/infrequent, and it is still a matter of debate whether two concurrent diseases in one patient are clonally related or represent independent aberrations.…”

Idiopathic thrombocytopenic purpura coexisting with polycythemia vera

“…Polycythemia vera (PV) coinciding with other hematological disorders[1–5] and idiopathic thrombocytopenic purpura (ITP) concomitantly associated with other blood-related neoplasm[67] have been sporadically described; however, ITP and PV coinciding in the same patient, as we have observed in three cases during the last 20 years, have not been described so far. All patients were men of 63, 68, and 77 years, respectively; they were referred to our attention because of the simultaneous finding of thrombocytopenia, with platelet counts ranging from 8 to 29 × 10 9 /l.…”