Wet etching of colossal magnetoresistive (CMR) perovskite La 0.67 (Sr 0.5 Ca 0.5 ) 0.33 MnO 3 (LSCMO) films on Bi 4 Ti 3 O 12 /CeO 2 /yttrium-stabilized zirconia (YSZ)-buffered Si substrates was investigated using potassium hydroxide (KOH) and buffered hydrofluoric acid (BHF) solutions. X-ray diffraction (XRD) and scanning spreading resistance microscopy (SSRM) measurements revealed that the morphological roughness of the LSCMO films increases, while the electrical resistance roughness decreases, with increasing KOH etching time. The LSCMO films are highly chemically resistant to KOH solution; however, in the case of BHF etching, an etch rate of 22 nm/min was obtained with high selectivity over a photoresist mask.