Two‐Dimensional Gold‐Tungsten Disulphide Bio‐Interface for High‐Throughput Electrocatalytic Nano‐Bioreactors

Parlak, Onur; Seshadri, Preethi; Lundström, Ingemar; Turner, Anthony P. F.; Tiwari, Ashutosh

doi:10.1002/admi.201400136

Cited by 19 publications

(13 citation statements)

References 22 publications

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“…The biosensor, first introduced by Leland C. Clark Jr. and co-workers in 1962 [1], is defined as an analytical device incorporating a biorecognition element within or associated with physiochemical transducers (classified as optical, electrochemical or mechanical [2][3][4]).…”

Section: Box 1 Biosensors and Enzymatic Electrochemical Detection Camentioning

confidence: 99%

Organic Electronics for Point-of-Care Metabolite Monitoring

Pappa

Parlak

Scheiblin

et al. 2018

Trends in Biotechnology

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In this review we focus on demonstrating how organic electronic materials can solve key problems in biosensing thanks to their unique material properties and implementation in innovative device configurations. We highlight specific examples where these materials solve multiple issues related to complex sensing environments, and we benchmark these examples by comparing them to state-of-the-art commercially available sensing using alternative technologies. We have categorized our examples by sample type, focusing on sensing from body fluids in vitro and on wearable sensors, which have attracted significant interest owing to their integration with everyday life activities. We finish by describing a future trend for in vivo, implantable sensors, which aims to build on current progress from sensing in biological fluids ex vivo.

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Section: Box 1 Biosensors and Enzymatic Electrochemical Detection Camentioning

confidence: 99%

Organic Electronics for Point-of-Care Metabolite Monitoring

Pappa

Parlak

Scheiblin

et al. 2018

Trends in Biotechnology

Self Cite

113

111

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“…It is also observed that the reduction peak potential (E pc ) after the immobilization of PNIPAAm and peroxidase on the nano‐hybrid assemble modified electrodes, shifted to negative values (Figure a) thus indicating that the forward (reduction) reaction requires more activation energy than similar reaction without the presence of PNIPAAm and peroxidase. This fact is also reinforced by the increased

Δ E_{p}

observed for the CV scans for the modified electrodes involving PNIPAAm and peroxidase .…”

Section: Resultsmentioning

confidence: 99%

Hierarchically Assembled Two‐dimensional Hybrid Nanointerfaces: A Platform for Bioelectronic Applications

et al. 2018

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We introduce a hybrid two‐dimensional nanointerface structure for bioelectronic systems. We fabricated smart hierarchically self‐assembled 2D electrobiocatalytic interface system based on the combination of gold nanoparticles doped graphene oxide (GO)‐molybdenum disulfide (MoS2) layered nanohybrid, conjugated with poly (N‐isopropylacrylamide, PNIPAAm) resulting in GO/AuNPs/MoS2/PNIPAAm interface. Horseradish peroxidase (HRP) was subsequently immobilized on the GO/AuNPs/MoS2/PNIPAAm interface through electrostatic interactions giving GO/AuNPs/MoS2/PNIPAAm/Peroxidase electrobiocatalytic interface system as a platform for electrobiocatalysis reactions for biosensing and bioelectronic applications. The electrobiocatalytic activity of the nanohybrid interface structure was studied using hydrogen peroxide (H2O2) as a model analyte. Cyclic Voltammetry showed diffusion controlled electron transfer properties at the interface. The fabricated bioelectrode exhibits a wide linear response to the detection of H2O2 from 1.57 to 11.33 mM, with a detection limit of 3.34 mM (S/N=3) and a capacitance of 8.6 F/cm2.

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“…The Randles circuit was chosen to fi t the impedance outputs. [ 23 ] The results are shown as Nyquist plots of spectra, which possess semicircular and linear portions. The plots contain two parts; the electron transfer limited (i.e., semicircular) and diffusion process (i.e., linear part) occurring at the same time.…”

Section: Doi: 101002/admi201500353mentioning

confidence: 99%