Two-lumen tubing is required for accurate barostat studies

Tam, Tiffany; Mui, H.; Jundler, S.; Tougas, Gervais; Armstrong, D.

doi:10.1016/s0016-5085(98)83446-x

Cited by 6 publications

(4 citation statements)

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“…Rectal compliance and sensation were recorded by a barostat‐manometric assembly comprising an ‘infinitely’ compliant 7‐cm long balloon with a maximum volume of 500 ml (Hefty Baggies; Mobil Chemical Co., Pittsford, NY, USA) linked to an electronic rigid piston barostat (Mayo Rigid Barostat; Engineering Department, Mayo Clinic, Rochester, MN, USA) by a double‐lumen tubing with a larger lumen (3.2 mm inner diameter) for balloon distention and a smaller lumen (2 mm diameter) for measuring pressure 14, 15 …”

Section: Methodsmentioning

confidence: 99%

Day‐to‐day reproducibility of anorectal sensorimotor assessments in healthy subjects

Bharucha

Seide

Fox

et al. 2004

Neurogastroenterology Motil

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The reproducibility of tests widely utilized to assess anorectal sensorimotor functions is not well established. Our aims were to assess the intra-individual day-to-day reproducibility of these parameters in healthy subjects. Anal sphincter pressures were assessed by perfusion manometry on two separate days in 19 healthy subjects. Rectal pressure-volume (p-v) curves and sensory thresholds were assessed in 12/19 subjects by inflating a highly compliant polyethylene balloon from 0 to 32 mmHg in 4 mmHg steps. Subjects also rated intensity of perception by visual analogue scale (VAS) during phasic distentions 8, 16 and 24 mmHg above operating pressure, in randomized sequence. Resting and squeeze anal pressures and rectal compliance were highly reproducible (r(s) > or = 0.7) in the same subject on separate days. Pressure thresholds for urgency appeared less reproducible than thresholds for initial perception and the desire to defecate. VAS scores were highly reproducible only during the 24-mmHg distention. Thus, anal pressures and rectal compliance are highly reproducible within healthy subjects on separate days, while sensory thresholds are reproducible to a variable degree, dependent on the intensity of stimulation and the perception being assessed.

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Section: Methodsmentioning

confidence: 99%

Day‐to‐day reproducibility of anorectal sensorimotor assessments in healthy subjects

Bharucha

Seide

Fox

et al. 2004

Neurogastroenterology Motil

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“…The balloon was linked to an electronic, rigid-piston barostat (Engineering Department, Mayo Clinic) by means of a double-lumen tube for balloon distension and intraballoon pressure measurement (56).…”

Section: Assessment Of Colonic Motor and Sensory Functionmentioning

confidence: 99%

Effects of a κ-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans

Delgado-Aros

Chial

Camilleri

et al. 2003

American Journal of Physiology-Gastrointestinal and Liver Physi

105

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ton, and Alan R. Zinsmeister. Effects of a -opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans. Am J Physiol Gastrointest Liver Physiol 284: G558-G566, 2003; 10.1152 10. /ajpgi.00360.2002pare the effects of the -opioid agonist asimadoline and placebo on visceral sensation and gastrointestinal (GI) motor functions in humans, 91 healthy participants were randomized in a double-blind fashion to 0.15, 0.5, or 1.5 mg of asimadoline or placebo orally twice a day for 9 days. We assessed satiation (nutrient drink test), colonic compliance, tone, perception of colonic distension (barostat), and whole gut transit (scintigraphy). Treatment effect was assessed by analysis of covariance. Asimadoline increased nutrient drink intake (P ϭ 0.03). Asimadoline decreased colonic tone during fasting (P ϭ 0.03) without affecting postprandial colonic contraction, compliance, or transit. Gas scores in response to colonic distension were decreased with 0.5 mg of asimadoline at low levels (8 mmHg above operating pressure) of distension (P ϭ 0.04) but not at higher levels of distension. Asimadoline at 1.5 mg increased gas scores at 16 mmHg of distension (P ϭ 0.03) and pain scores at distensions of 8 and 16 mmHg (P ϭ 0.003 and 0.03, respectively) but not at higher levels of distension. Further studies of this compound in diseases with altered satiation or visceral sensation are warranted. sensation; visceral; stomach; colon; barostat VISCERAL PAIN AND DISCOMFORT are relevant clinical features of many medical processes, including functional gastrointestinal (GI) disorders (57). These are frequent and chronic-relapsing conditions with a great impact on quality of life (23), yet no satisfactory treatment is available for treatment of pain in these highly prevalent conditions.The three major opioid receptors, , ␦, and , are distributed in the peripheral and central nervous systems (45, 53) and are known to modulate visceral nociception (16,22,29).

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“…A polyethylene balloon barostat-manometric assembly was placed into the prepared upper descending colon using flexible sigmoidoscopy and fluoroscopy (2). The assembly was comprised of an infinitely compliant 10-cm-long balloon with a maximum volume of 600 ml (Hefty Baggies; Mobil Chemical, Pittsford, NY) linked to an electronic rigid-piston barostat (Mayo Rigid Barostat, Engineering Department, Mayo Clinic, Rochester, MN) by a double-lumen tubing with a larger lumen (3.2 mm inner diameter) for balloon distension and a smaller lumen (2 mm diameter) for measuring pressure (18). The manometric portion of the assembly was comprised of six water-perfused (0.4 ml/min) pneumohydraulic transducers 5 cm apart.…”

Section: Colonic and Rectal Motor Functionmentioning

confidence: 99%

Rectal and colonic distension elicit viscerovisceral reflexes in humans

Law¹,

Bharucha²,

Zinsmeister

2002

American Journal of Physiology-Gastrointestinal and Liver Physi

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Colonic transit is slowed in patients with disordered rectal evacuation, but the mechanism of this phenomenon is unclear. Our objective was to investigate rectocolonic inhibitory reflexes in humans to provide potential insight into patients with obstructed defecation. In 30 healthy subjects, a barostat-manometric assembly recorded colonic tone and phasic activity in the descending colon during rectal distension and recorded rectal tone during colonic distension. Phasic distensions were 8, 16, and 32 mmHg above balloon operating pressure, and staircase inflations were comprised of balloon inflation then deflation in 2-mmHg increments at 30-s intervals from 0 to 36 mmHg. Colonic balloon volumes increased to a similar extent during phasic rectal distensions 8, 16, and 32 mmHg above operating pressure, reflecting reduced colonic tone; balloon volumes also increased and phasic pressure activity decreased during staircase rectal distensions. In contrast, rectal balloon volume declined, reflecting increased tone during phasic and staircase colonic distensions. Thus rectal distension inhibited colonic motor activity, indicative of a viscerovisceral inhibitory reflex.

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Two-lumen tubing is required for accurate barostat studies

Cited by 6 publications

References 0 publications

Day‐to‐day reproducibility of anorectal sensorimotor assessments in healthy subjects

Day‐to‐day reproducibility of anorectal sensorimotor assessments in healthy subjects

Effects of a κ-opioid agonist, asimadoline, on satiation and GI motor and sensory functions in humans

Rectal and colonic distension elicit viscerovisceral reflexes in humans

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