Two new <i>N</i>-acetyl-ᴅ-glucosamine derivatives from the medical algae-derived endophytic fungus <i>Penicillium chrysogenum</i>

Chen, Jing; Huo, Li-Na; Gao, Yuan; Zhang, Yunli; Chen, Ye

doi:10.1080/14786419.2021.1889543

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…Further meroterpenoids were obtained from P. chermesinum ( 644 – 647 ) 218 and P. chrysogenum ( 648 – 650 ), 219 (the latter group via mutation with diethyl sulfate) and indole diterpenoids, paspalines C–D 651 , 652 and paxillines B–D 653 – 655 , 220 N -acetyl- d -glucosamine derivatives 656 , 657 , 221 citreoviridins J–O 658 – 663 , 222 pentacyclic alkaloid 664 , 223 dipeptide 665 (ref. 224) and eremophilane-type sesquiterpenes 666 – 677 (ref.…”

Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

Carroll,

Copp,

Grkovic

et al. 2024

Nat. Prod. Rep.

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Section: Marine Microorganisms and Phytoplanktonmentioning

confidence: 99%

Marine natural products

Carroll,

Copp,

Grkovic

et al. 2024

Nat. Prod. Rep.

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“…Among Penicillium species able to produce cytotoxic SMs is the endophytic fungus P. chrysogenum , from the marine medical red alga Grateloupia turuturu [ 150 ]. Through in vitro assay, it was possible to demonstrate the cytotoxicity activity of the N-acetyl--glucosamine derivatives, penichryfurans A and B against A549, HeLa, and HepG2 cell lines.…”

Section: Studies Of Fungal Secondary Metabolites As Cytotoxic and Ant...mentioning

confidence: 99%

Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds

et al. 2022

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Microorganisms are known as important sources of natural compounds that have been studied and applied for different purposes in distinct areas. Specifically, in the pharmaceutical area, fungi have been explored mainly as sources of antibiotics, antiviral, anti-inflammatory, enzyme inhibitors, hypercholesteremic, antineoplastic/antitumor, immunomodulators, and immunosuppressants agents. However, historically, the high demand for new antimicrobial and antitumor agents has not been sufficiently attended by the drug discovery process, highlighting the relevance of intensifying studies to reach sustainable employment of the huge world biodiversity, including the microorganisms. Therefore, this review describes the main approaches and tools applied in the search for bioactive secondary metabolites, as well as presents several examples of compounds produced by different fungi species with proven pharmacological effects and additional examples of fungal cytotoxic and antimicrobial molecules. The review does not cover all fungal secondary metabolites already described; however, it presents some reports that can be useful at any phase of the drug discovery process, mainly for pharmaceutical applications.

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“…Dictyota dichotoma Penicillium chrysogenum inhabited Grateloupia turuturu (Rhodophyta) (Dellai et al, 2013;El-Shaibany et al, 2020;Zhang et al, 2020a;Chen et al, 2021a) Anti-bacterial Chlorellin Fatty acids Terpenes Polysaccharides…”

Section: Sargassum Fusiformementioning

confidence: 99%

“…Interestingly, besides medical algae, some symbiotic bacteria of algae can also produce substances with cytotoxic activity for anti-cancer. In a study by Chen et al (2021a), penichryfurans A (1), a new Nacetyl-glucosamine derivatives from an endophytic fungus Penicillium chrysogenum which inhabited Grateloupia turuturu (Rhodophyta), exhibited strong cytotoxicity towards the HepG2 cell line.…”

Section: Fucus Vesiculosusmentioning

confidence: 99%

Remarkable Natural Biological Resource of Algae for Medical Applications

Dai

Wang²,

Xu³

et al. 2022

Front. Mar. Sci.

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With increasing consumer awareness of the use of natural products in pharmaceuticals and medicine, it is noted that algae can be considered an appropriate source. Algae produce many bioactive components, which have application potential in pharmaceutical industries, such as fatty acids, phycobiliprotein, polysaccharides, phenolic compounds, carotenoids, and so on. However, it is still a long way before the truly widespread application of algae in medicine, and some research and technical bottlenecks still need to be resolved for further practical use. Here, we provide an in-depth review of the current understanding of algal-based medical application, with a focus on the main pharmaceutical activity and current application stage including in vitro, animal, and clinical studies. Furthermore, we propose some possible solutions to the obstacles that should be overcome for achieving the practical applications of algal-based medicine. Notably, animal and clinical studies on algal drugs and treatments should continue to push forward and expand for promoting the practical applications. Moreover, the developments in interdisciplinary research of algal biology and other disciplines provide new insight for driving algae-based medical application.

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Two new N-acetyl-ᴅ-glucosamine derivatives from the medical algae-derived endophytic fungus Penicillium chrysogenum

Cited by 9 publications

References 9 publications

Marine natural products

Marine natural products

Overview of Bioactive Fungal Secondary Metabolites: Cytotoxic and Antimicrobial Compounds

Remarkable Natural Biological Resource of Algae for Medical Applications

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