Two new prenylated flavonoids from the seeds of Psoralea corylifolia with their inhibitory activity on α-glucosidase

Fei, Wenting; Zhang, Jianjun; Tang, Ru-Ying; Yue, Na; Zhou, Xuelin; Wang, Linyuan

doi:10.1016/j.phytol.2020.07.005

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…Three 8-prenylflavonones euchrenone a7 ( 279 ), 8-prenylnaringenin ( 280 ), and isoxanthohumol ( 281 ) from Morus alba and H. lupulus showed inhibition activities against α -glucosidase with IC 50 values of 6.28, 50, and 40 µ M, respectively (Wang et al 2022 ; Yang et al 2012 ). 4′,1′′-Dihydroxy-3′-methoxy-6,7-furanflavanone ( 349 ) is from the seeds of Psoralea corylifolia and exhibited inhibitory activity on α -glucosidase with an IC 50 value of 53.1 µ M, lower than the positive control acarbose (IC 50 = 214.5 µ M) (Fei et al 2020 ). Four geranylated flavonones nymphaeol A ( 367 ), 437 , 438 , and 445 , isolated from Okinawa propolis , strongly suppressed in vitro α -glucosidase enzyme activity with IC 50 values of 3.77–5.66 µ M (Shahinozzaman et al 2018 ).…”

Section: Prenylated Flavonoids With Anti-inflammatory Activitymentioning

confidence: 99%

“…579 showed α -glucosidase inhibitory activity with an IC 50 value of 47 µ M below that of positive control acarbose (IC 50 = 58 µ M) (Wang et al 2022 ). 5,3′,4′-trihydroxy-1′′-methoxy-6,7-furanbavachalcone ( 609 ) is from the seeds of Psoralea corylifolia and exhibited inhibitory activity on α -glucosidase with an IC 50 value of 90.3 µ M. The IC 50 value of the positive control acarbose was 214.5 µ M (Fei et al 2020 ). A phytochemical investigation of Masclura tricuspidata leaves resulted in the isolation of 47 prenylated isoflavonoids.…”

Section: Prenylated Flavonoids With Anti-inflammatory Activitymentioning

confidence: 99%

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Phytochemistry and pharmacology of natural prenylated flavonoids

Wang

Luo

et al. 2023

Arch. Pharm. Res.

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Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain enriched the structural diversity of flavonoids and increased their bioactivity and bioavailability. Prenylated flavonoids show a wide range of biological activities, such as anti-cancer, anti-inflammatory, neuroprotective, anti-diabetic, anti-obesity, cardioprotective effects, and anti-osteoclastogenic activities. In recent years, many compounds with significant activity have been discovered with the continuous excavation of the medicinal value of prenylated flavonoids, and have attracted the extensive attention of pharmacologists. This review summarizes recent progress on research into natural active prenylated flavonoids to promote new discoveries of their medicinal value. Supplementary Information The online version contains supplementary material available at 10.1007/s12272-023-01443-4.

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Section: Prenylated Flavonoids With Anti-inflammatory Activitymentioning

confidence: 99%

Section: Prenylated Flavonoids With Anti-inflammatory Activitymentioning

confidence: 99%

Phytochemistry and pharmacology of natural prenylated flavonoids

Wang

Luo

et al. 2023

Arch. Pharm. Res.

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Psoralea corylifolia L.: Panacea to several maladies

Mahajan

Koul

Gupta

et al. 2022

South African Journal of Botany

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An Overview of Biological Importance, Pharmacological Aspects, and Analytical Techniques of Bavachin from Psoralea corylifolia Linn.

Patel

2023

CFF

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Background: Psoralea corylifolia Linn belongs to Leguminosae family is commonly known as ‘Bakuchi’ in Ayurvedic system of medicine. P. corylifolia is an important medicinal herb used for the treatment of Leucoderma, psoriasis and leprosy. P. corylifolia seed contain psoralen, psoralidin, isopsoralen, neobavaisoflavone, corylin, bavachin, and bavachalcone. P. corylifolia has been used for the treatment of asthma, vitiligo, nephritis, calvities and cough. Bavachin is a pure phytochemical, found to be present in the seeds and fruit of P. corylifolia. Methods: In order to know the medicinal properties and therapeutic benefit of bavachin in the medicine, numerous scientific research data have been collected from different literature sources and analyzed. Medicinal importance and pharmacological activities of bavachin has been investigated through literature data analysis of different scientific research works. Scientific research data has been collected from databases such as PubMed, Google, Google Scholar, Science Direct, and Scopus using words Psoralea corylifolia and bavachin. Further maximum scientific article of bavachin with respect to its pharmacological activities, medicinal importance, and analytical data of has been collected from these databases and presented here with proper citation. Results: Data analysis of scientific research works of bavachin revealed the biological importance of bavachin in the medicine. Bavachin showed anti-inﬂammatory, anticancer, anti-bacterial, lipid-lowering and cholesterol-reducing properties in the medicine. Bavachin has multiple pharmacological activities including platelet aggregation, α-glucosidase activities and antibacterial potential. Bavachin has a potential estrogen supplement for estrogen replacement therapy. Present work summarized biological potential of bavachin on inflammatory disorders, articular cartilage degeneration, cardiovascular disease, hyperglycemia, Parkinson's disease, Alzheimer's disease, apoptosis, melanin synthesis, estrogen Receptor, UDP-glucuronosyltransferase 1A1 and various form of pathogenic infection. Analytical data revealed the significance of an HPLC-UV, HPLC, HPLC-ECD, HPLC-DAD, IT-MS, HPLC, HPLC/TOF-MS, LC-MS/MS and ILUAE techniques for separation, identification and quantification of bavachin in different samples. Conclusion: Literature data analysis revealed the biological importance and therapeutic potential of bavachin in the medicine for the treatment of various form of human disorders.

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Two new prenylated flavonoids from the seeds of Psoralea corylifolia with their inhibitory activity on α-glucosidase

Cited by 4 publications

References 16 publications

Phytochemistry and pharmacology of natural prenylated flavonoids

Phytochemistry and pharmacology of natural prenylated flavonoids

Psoralea corylifolia L.: Panacea to several maladies

An Overview of Biological Importance, Pharmacological Aspects, and Analytical Techniques of Bavachin from Psoralea corylifolia Linn.

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