Two New Sesquiterpenes from the Stems of Fissistigma maclurei

Two new aporphine-derived alkaloids, aporaloids C and D (1 and 2), along with eight known biogenetically related alkaloids (3-10) were isolated from the stems of Fissistigma maclurei Merr.. Their structures were elucidated by detailed analysis of NMR, HRESIMS, MS, IR, UV and Optical rotations data. Compounds 1 and 2 represent a rare example of N-methylol aporphine-derived alkaloids from natural sources. The inhibitory effect of all compounds on the proliferation of primary synovial cells was evaluated. Compound 3 showed potent inhibitory effect on the proliferation of synoviocytes with an IC 50 value of 4.8 μM.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Two New Sesquiterpenes from the Stems of Fissistigma maclurei

Cited by 2 publications

References 6 publications

Three new indole alkaloid derivatives from Fissistigma oldhamii Levl. and their anti-inflammatory effects

Three new indole alkaloid derivatives from Fissistigma oldhamii Levl. and their anti-inflammatory effects

Alkaloids from the stems of Fissistigma maclurei Merr. inhibit the proliferation of synoviocytes

Contact Info

Product

Resources

About