Two novel xanthones from Garcinia mangostana

Gopalakrishnan, Geetha; Balaganesan, Banumathy

doi:10.1016/s0367-326x(00)00199-4

Cited by 19 publications

(7 citation statements)

References 7 publications

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“…). The follow‐up isolation study on the chloroform‐soluble extract led to the identification of 13 compounds including α‐mangostin (1), β‐mangostin (2), γ‐mangostin (3), 1‐isomangostin (4), gartanin (5), garcinone D (6), 9‐hydroxycalabaxanthone (7), smeathxanthone A (8), tovophyllin A (9), 8‐deoxygartanin (10), mangostanin (11), calocalabaxanthone (12), and 1,7‐dihydroxy‐3‐methoxy‐2‐(3‐methylbut‐2‐enyl) xanthen‐9‐one (13), confirmed by comparison of the measured values with the published values (Fig. ).…”

Section: Resultsmentioning

confidence: 99%

Xanthones with pancreatic lipase inhibitory activity from the pericarps of Garcinia mangostana L. (Guttiferae)

Chae

Kim

Han

et al. 2016

Euro J Lipid Sci & Tech

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Bioactivity-guided isolation of natural compounds from the pericarps of Garcinia mangostana, using a pancreatic lipase assay, led to the identification of 13 xanthones including a-mangostin (1), b-mangostin (2), g-mangostin (3), 1-isomangostin (4), gartanin (5), garcinone D (6), 9-hydroxycalabaxanthone (7), smeathxanthone A (8), tovophyllin A (9), 8-deoxygartanin (10), mangostanin (11), calocalabaxanthone (12), and 1,7-dihydroxy-3-methoxy-2-(3-methylbut-2-enyl) xanthen-9-one (13). The inhibitory activities of the isolated xanthones against pancreatic lipase were evaluated and a-mangostin (1) was found to possess the most potent inhibitory activity (IC 50 5.0 mM) in a non-competitive manner, compared with the positive control, orlistat (IC 50 3.9 mM).Practical applications: Pancreatic lipase is a key enzyme in lipid absorption. A total of 13 compounds were isolated from the pericarps of G. mangostana. Their structures were characterized by HRESI-MS, and 1D and 2D-NMR spectroscopic data. Our results show that all the isolates exhibited inhibitory activity against pancreatic lipase. Of the active xanthones, a-mangostin displayed the most potent lipase inhibition, with an IC 50 value of 5.0 mM. Furthermore, kinetic analysis of a-mangostin was carried out. In the Lineweaver-Burk plot, the apparent V max values in the presence of 1, 2, 4, and 10 mM a-mangostin were decreased compared with those without a-mangostin, whereas the K m values of 4-MU oleate with and without a-mangostin were both close to 3.22 mM. Finally, it is evident that xanthone derivatives isolated from G. mangostana possess pancreatic lipase inhibitory activities.

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Section: Resultsmentioning

confidence: 99%

Xanthones with pancreatic lipase inhibitory activity from the pericarps of Garcinia mangostana L. (Guttiferae)

Chae

Kim

Han

et al. 2016

Euro J Lipid Sci & Tech

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“…These xanthones have been isolated from plants of the family Clusiaceae (Garcinia [171] and Calophyllum [62,71,88,89] species), as well as from the marine-derived fungus Emericella variecolor [37,172] from which a new compound varixanthone (225) was isolated. This xanthone showed antimicrobial activity against Escherichia coli, Proteus sp., Bacillus subtilis and Staphylococcus aureus [47,73] Garcinia intermedia [20] Garcinia mangostana [36,191] Garcinia merguensis [30] Garcinia nigrolineata [35] Maclura tinctoria [18] Allanxanthone A (239) * R 1 =A; R 2 =C; R 3 =H Allanblackia floribunda [22] Calophyllum caledonicum [192] (±)-Dicaledol (240) * R 1 =R 2 =E; R 3 =H Calophyllum caledonicum [175] Nigrolineaxanthone N (241) * R 1 =A; R 2 =H; R 3 =B Garcinia nigrolineata [ [20,47,73] Calophyllum inophyllum [74,193] Cudrania cochinchinensis [173] Garcinia merguensis [30] Garcinia nigrolineata [31] Vismia latifolia [194] 1,5-Dihydroxy-6'-methyl-6'-(4-methyl-3-pentenyl)-pyrano-(2'3':3:2)-xanthone (263) * R=A Garcinia merguensis [30] Kielmeyera lathrophyton [46] O O OH…”

Section: Prenylated Di-oxygenated Xanthonesmentioning

confidence: 99%

Naturally-Occurring Xanthones: Recent Developments

Vieira

Kijjoa²

2005

CMC

176

132

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A literature survey covering the report of naturally occurring xanthones from January 2000 to December 2004, with 219 references, is presented in this review. Among 515 xanthones reported in this period, 278 were new natural xanthones. These xanthones have been identified from 20 families of higher plants (122 species in 44 genera), fungi (19 species) and lichens (3 species). The structural formulas of 368 identified xanthones, their distribution and a brief mention of their biological properties are also included.

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“…Ethnomedical uses of G. mangostana include dysentery, diarrhea, cystitis, gonorrhea, gleet, astringent lotion, eczema, and other skin disorders (Chiu & Chang, 1986). It has been reported in literature that xanthones such as a-and b-mangostins, mangostenol, mangostenone A, trapezifolixanthone, tovophyllin B, and garcinone B, along with flavonoids, epicatechin, resin, and tannins, are frequently isolated from the fruit rind of G. mangostana (Gopalakrishnan & Balaganesan, 2000;Huang, Chen, Chen, Huang, & Shieh, 2001;Suksamrarn, Suwannapoch, Ratananukul, Aroonlerk, & Suksamrarn, 2002).…”

Section: Article In Pressmentioning

confidence: 99%