Two species of antiganglioside antibodies in a patient with a pharyngeal-cervical-brachial variant of Guillain-Barre syndrome.

Abstract

A patient with a pharyngeal-cervicalbrachial variant of GuilIlain-Barre' syndrome had anti-GTla and anti-GDla antibodies (IgG) in the serum. The activities of anti-GTla antibodies were stronger than anti-GDla antibodies and their activities declined later in the clinical course. These two different antibodies bound independently to each ganglioside in an absorption study with polystyrene beads coated with GTla or GDla. motor nerve conduction velocity studies showed that compound action potentials of the ulnar and peroneal nerves were normalised by the 24th day. He was discharged 60 days after admission with almost full recovery except for the facial and neck muscles. The strength of his neck muscles had fully recovered by three months and his facial muscles by six months after discharge.Methods ENZYME LINKED IMMUNOSORBENT ASSAY

Fulminant Guillain-Barre Syndrome after Campylobacter jejuni Enteritis and Monospecific Anti-GT1a IgG Antibody.

“…This characteristic pattern of muscle weakness indicates another variant of GBS, termed pharyngeal-cervical-brachial (PCB) variant ( 1 3). Several patients have been described as having PCBweakness and anti-GTla IgG antibody which did not cross-react with GQlb, indicative of a causal relationship between PCBweakness and anti-GTl a antibody in GBS (8)(9)(10). These patients showed good recovery whether or not there was mild involvement of the limbs.…”

“…Anti-GTla IgG antibody in our patient seems to have functioned in the development of severe GBSafter C. jejuni enteritis, because GTla ganglioside was found in the peripheral nerves of humans (3). In previous GBScases with anti-GTla IgG antibody without anti-GQlb activity, preferential paralysis of the cranial nerves and axial muscles occurred (8)(9)(10)(11)(12). All the patients had bulbar palsy and some had ophthalmoparesis.…”

A Rare Form of Guillan Barre Syndrome: A Child Diagnosed with AntiGD1a and Anti-GD1b Positive Pharyngeal-Cervical-Brachial Variant

“…Marked extremity weakness along with facial nerve paralysis and ophthalmoplegia have been reported in 45% of affected children. In 15% of cases, proximal muscle weakness might be more prominent (6). There are different variants of GBS manifesting themselves with atypical clinical and electrophysiological findings.…”

Detection of Serum Anti-ganglioside Antibodies by Latex Agglutination Assay in Guillain-Barre Syndrome: Comparison with ELISA

“…Serum anti-ganglioside antibodies have been assayed by thin-layer chromatography (TLC) or enzyme-linked immunosorbent assay (ELISA) in patients with Guillain-Barre syndrome (GBS), and its variant Miller Fisher syndrome (MFS) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). As a result of this prevalence, it is known that some types of anti-ganglioside antibodies are specifically linked with the antecedent events or clinical features in GBS.…”