Recently, multi-energy systems based on energy hub are introduced because of significant benefits in reducing energy and emission cost. This paper proposed an optimal schedule model of multi-energy hubs networks consisting of energy hubs, renewable sources, and energy storage which are connected by electrical and natural gas distribution networks. In the proposed mixedinteger nonlinear programming model, the objective is to minimize the operation, energy, and emission costs of energy hubs with both renewable sources and storage and energy distribution networks. The proposed schedule framework allows simultaneously selections of optimal operation structure of EHs together with the optimal operation parameters of energy distribution networks and therefore this model can maximize the profit of the entire largescale multi-energy hubs network. Besides, the operation parameters and energy loss of both electrical and natural gas distribution networks are considered in conjunction with optimal operation of energy hubs and thus guarantee the operation and optimization of the network in all operational scenarios. The IEEE 5-bus test system is utilized to demonstrate the applicability of the proposed model. The simulation results show the feasibility of the proposed model, and demonstrate that the energy hubs, renewable sources, and energy storage in the proposed structure significantly enhance the efficiency of the multi-energy hubs network by reducing not only energy and operation costs but also emission..