Two Wavelengths Dependant Stability Indicating Spectrophotometric Methods for Determination of Labetalol Hydrochloride in the Presence of its Oxidative Degradation Product: A Comparative Study

Attia, Khalid A.M.; El-Abassawi, Nasr M.; Ramzy, Sherif

doi:10.1080/22297928.2015.1135077

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Where, mSAC1,2 and mVAL1,2 are the slopes of the components SAC and VAL at the two selected wavelengths [16][17][18] . The determinants of these matrices were calculated and the wavelength set selected for which the highest matrix determinant value was obtained, Table 2.…”

Section: Bivariate Methods (Bm)mentioning

confidence: 99%

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Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Attia

Nassar

El‐Olemy

et al. 2018

Journal of Advanced Pharmacy Research

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Objectives: Simultaneous estimation of sacubitril and valsartan in their new pharmaceutical tablets by bivariate method and two multivariate methods namely; classical least square and principal component regression. Methods: (A) Bivariate method, where absorbance values were measured at two optimum wavelengths (220 nm and 250 nm). (B) Multivariate methods, where partial factorial design was constructed within the wavelength range from 210-290nm at 1 nm interval. Results: The bivariate method is based on simple mathematic algorithm using two optimum wavelengths for the analysis of the mixture. On the other hand, two multivariate methods considering all the variables at the same time have been used to improve the quality of spectral analysis of the mixture. Conclusion: The proposed methods have been successfully applied for the determination of the two drugs in Entresto ® tablets. Statistical comparisons between the obtained results and those obtained by the reported method have been performed showing no significant differences by applying t-test and F-test.

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Section: Bivariate Methods (Bm)mentioning

confidence: 99%

“…Hence, the aim of this work is to develop three spectrophotometric methods for simultaneous determination of SAC and VAL in their pharmaceutical tablets. The developed methods are bivariate method (BM) [15][16][17][18][19] , classical least square (CLS) and principal component regression (PCR) [20][21][22][23] .…”

Section: Entrestomentioning

confidence: 99%

Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Attia

Nassar

El‐Olemy

et al. 2018

Journal of Advanced Pharmacy Research

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“…UV detection can be performed classically by UV spectrophotometry. It can also be achieved by coupling with HPLC, TLC and capillary electrophoresis techniques, with a significant difference in sensitivity [1][2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Application of different quantitative analytical techniques for estimation of aspirin and omeprazole in pharmaceutical preparation

Abdelazim

Ramzy

2022

BMC Chemistry

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Several quantitative analytical methods were used to estimate aspirin and omeprazole in recently FDA-approved tablets. The first derivative of the ratio spectra was used to resolve the recorded overlapping spectra between aspirin and omeprazole. The first derivative of the ratio spectra of the studied drug mixtures was divided by a spectrum of a standard solution of omeprazole for the estimation of aspirin. Also, the first derivative of the ratio spectra of the studied drug mixtures was divided by a spectrum of the standard solution of aspirin for the estimation of omeprazole. For the simultaneous quantitative analysis of aspirin and omeprazole, the TLC densitometry technique was applied using TLC aluminum silica gel plates, toluene–acetonitrile–methanol (7:2:0.5, by volume) as the mobile phase, and UV detection at 272 nm. The advantages and disadvantages of the proposed techniques were discussed in the context of the results and the sensitivity limits of the methods. The proposed techniques were validated and successfully applied to the analysis of drugs in pure and pharmaceutical forms. A statistical comparison of the data obtained by the described methods with other data obtained by a previously published HPLC method was performed. The results agreed well with respect to the recommended statistical tests. Furthermore, the greenness of the described methods was assessed using different tools, the analytical eco-scale, the green analytical procedure index and the AGREE evaluation method. The proposed methods showed more adherence to the greenness characters in comparison to the previously reported HPLC method.

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The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol

Haque,

Aldhafeeri,

Rahman

et al. 2024

J Pharm Innov

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Two Wavelengths Dependant Stability Indicating Spectrophotometric Methods for Determination of Labetalol Hydrochloride in the Presence of its Oxidative Degradation Product: A Comparative Study

Cited by 6 publications

References 20 publications

Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Application of different quantitative analytical techniques for estimation of aspirin and omeprazole in pharmaceutical preparation

The Application of Box-Behnken-Design in the Optimization of Kinetic Spectrophotometry and Computational Studies to Determine and Assessing Eco-Scale to Green Analytical Chemistry for Labetalol

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