Two-way, unfolded three-way and three-mode partial least squares calibration of diode array HPLC chromatograms for the quantitation of low-level pharmaceutical impurities

Simultaneous Spectrophotometric Determination of Hg2+, Pb2+, and Cu2+ by Zn(dmit) Using the Multivariate Calibration Method

“…The complex [NBu4]2[Zn(dmit)2] was prepared according to the literature. 3 All solutions were prepared with ultra-pure water.…”

“…In this respect, the uses of multivariate calibration methods have grown rapidly, gaining popularity in the determination of metal concentrations in complex mixtures. Some common multivariate calibration methods are Multiple Linear Regression (MLR), 2 Partial Least Square (PLS), 3,4 Principal Component Regression (PCR), [5][6][7] and the K matrix method. 4,8,9 Up to now, many multicomponent calibration methods have been developed, and undoubtedly new methods will be developed in the future.…”

Comparative study of the continuous wavelet transform, derivative and partial least squares methods applied to the overlapping spectra for the simultaneous quantitative resolution of ascorbic acid and acetylsalicylic acid in effervescent tablets

“…However, the advent of the new mathematical methods, namely the wavelet transforms [12][13][14][15][16][17][18] and the chemometric methods [19][20][21][22] have fostered the development of the curve resolution of the overlapping peaks in the spectra of multi-mixtures. In analytical chemistry, the wavelet method has been used in combination of other calibration techniques such as partial least squares (PLS) [23][24][25] and zero-crossing techniques [26][27][28] for the quantitative determination of active compounds in samples.…”

“…Continuous wavelet transform (CWT) method is a quite new and promising method in the area of pharmaceutical [21][22][23] and other signal processing area. The importance of CWT comes from the signal transformation of the original one to the other form of signal giving opportunity of many families including Haar, Daubechies and Mexican hat function to obtain the best calibration signals.…”

N-way PLS applied to simultaneous spectrophotometric determination of acetylsalicylic acid, paracetamol and caffeine

“…A three-way array may be obtained by collecting data tables with a fixed set of objects and variables under different experimenhas recently received more attention than other tools. Its applications can be found on HPLC-DAD [4], molecular fluorescence spectrometry [5,6], 3D-QSAR [7], MS/MS [8] UV-Vis spectroscopic-kinetic data [9], image analysis [10], remote sensing [11] and industrial pharmaceutical batch process [12]. An example of a four-way-PLS application can be found on kinetic spectrofluorimetry data [13].…”