Two‐year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study

Agarwal, Pratibha; Loh, S. K. E.; Lim, Sok Bee; Sriram, Bhavani; Daniel, Mary; Yeo, S.; Heng, Derrick

doi:10.1111/j.1471-0528.2005.00663.x

Cited by 49 publications

(35 citation statements)

References 28 publications

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“…34 They were approximately 2 years of age and, like another contemporaneous study using the Griffith scale of mental development, 1 no problems were found in relation to sperm concentration, morphology or motility. In other words, the severity of the sperm defect in the father did not affect neurodevelopmental outcome in these young children.…”

Section: Growth and Neurodevelopmentmentioning

confidence: 64%

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Outcomes for offspring of men having ICSI for male factor infertility

Halliday¹

2011

Asian J Androl

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Since the introduction of intracytoplasmic sperm injection (ICSI) using single sperm isolated from testicular tissue in men with obstructive and non-obstructive azoospermia, or using ejaculated sperm in those with poor semen quality, there have been concerns that this might have adverse effects on the offspring compared to conventional in vitro fertilisation (IVF) and natural conceptions. ICSI is done for reasons other than male factor infertility, and on the whole has not been shown to have any more negative effects than those seen with IVF. There have however, been very few studies of ICSI with a focus on, or large enough numbers to examine, the specific outcomes associated with male factor infertility. From the limited information available in relation to the source of the sperm and aetiology of infertility in the presence of ICSI, there appears to be no increased risk of congenital malformations. There is, however, a small increase in both de novo and inherited chromosome abnormalities. In terms of growth and neurodevelopment, there are very few studies, and so far, no adverse outcomes have been found in young children whose fathers have a sperm defect. The origin of the sperm used in ICSI does not have a major influence on the early life outcomes for the offspring, but transgenerational and epigenetic effects remain unknown. When the male factor infertility is known or thought to be due to a Y-chromosome deletion, this information should be given to the young male offspring at a time that will ensure his own reproductive health and plans are optimized.

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Section: Growth and Neurodevelopmentmentioning

confidence: 64%

“…34 They too, like the United Kingdom group, found slight evidence of an increase in adverse outcomes with severe oligozoospermia, but the numbers are far too small to place importance on.…”

Section: Overall Defectsmentioning

confidence: 98%

Outcomes for offspring of men having ICSI for male factor infertility

Halliday¹

2011

Asian J Androl

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“…However, a mutation in the KIF21A gene, which was identified in congenital fibrosis of extraocular muscles type 1, has been reported in cases of MS accompanied by additional eye movement disorder (3). In the medical literature, a case of MS and a patient with Hanhart syndrome involving Moebius sequence in relation with intracytoplasmic sperm injection (ICSI), which is one of the assisted reproductive techniques, have been reported (4,5). Our patient was born by way of in vitro fertilization and we could no other case reports in relation with in vitro fertilization in the medical literature.…”

Section: Introductionmentioning

confidence: 80%

“…Studies have shown that some major and/or minor anomalies occur more commonly in babies of mothers who became pregnant by way of assisted reproductive techniques compared with groups that were pregnant through intercourse (2). A case of MS and a case of Hanhart syndrome (MS-associated syndrome) in relation with the intracytoplasmic sperm injection method have been reported previously (4,5). Although studies conducted in recent years have reported that there was no increase in the general risk of congenital anomaly in relation with in vitro fertilization, an increased risk has been reported in under certain conditions (10).…”

Section: Discussionmentioning

confidence: 99%

A congenital cranial dysinnervation disorder: Möbius’ syndrome

Albayrak¹,

Tarakçı²,

Altunhan³

et al. 2017

Turk Pediatri Ars

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Möbius' syndrome, also known as Möbius' sequence, is a nonprogressive cranial dysinnervation disorder characterized by congenital facial and abducens nerve paralysis. Here, we report a 5-day-old girl who was conceived after in vitro fertilization with poor suck and facial paralysis. She had bilaterally ptosis and lateral gaze limitation, left-sided deviation of the tongue, dysmorphic face, hypoplastic fingers and finger nails on the left hand, and was diagnosed as having Möbius' syndrome. Involvement of other cranial nerves such as three, four, five, nine, 10 and 12, and limb malformations may accompany this syndrome. However, several factors have been proposed for the etiology, some rare cases have also been reported with artificial reproductive technologies. Feeding difficulties and aspiration are the main problems encountered in infancy. The other cranial nerves should be examined further in newborns who present with congenital facial palsy, and other cranial dysinnervation disorders should be considered in the differential diagnosis.

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“…6,7 The physical, neurological, and developmental health of children born after ART has been examined in many epidemiological studies, with contradictory results. Most small studies reported no effect, [24][25][26][27][28][29][30][31] whereas the larger studies have found an increased risk of developmental delay. [32][33][34][35] A recent systematic review and meta-analysis has also addressed the question of developmental delay in children born after ART.…”

Section: Estradiol (Nmol/l)mentioning

confidence: 99%

Impact of Controlled Ovarian Hyperstimulation on Thyroid Function

Fleischer¹,

Müller²,

Jong³

et al. 2014

Reproductive Biology Insights

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OBJECTIVE:To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E 2 ), thyroxine binding globulin (TBG), free thyroxine (FT 4 ), total thyroxine (TT 4 ) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E 2 , TBG, and TT 4 were significantly higher; midluteal FT 4 was significantly lower (mean difference: -1.46 pmol/L; P  0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT 4 and higher midluteal TSH levels compared to the natural cycle.

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Two‐year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study

Cited by 49 publications

References 28 publications

Outcomes for offspring of men having ICSI for male factor infertility

Outcomes for offspring of men having ICSI for male factor infertility

A congenital cranial dysinnervation disorder: Möbius’ syndrome

Impact of Controlled Ovarian Hyperstimulation on Thyroid Function

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