A congenital cranial dysinnervation disorder: Möbius’ syndrome

Abstract

Möbius' syndrome, also known as Möbius' sequence, is a nonprogressive cranial dysinnervation disorder characterized by congenital facial and abducens nerve paralysis. Here, we report a 5-day-old girl who was conceived after in vitro fertilization with poor suck and facial paralysis. She had bilaterally ptosis and lateral gaze limitation, left-sided deviation of the tongue, dysmorphic face, hypoplastic fingers and finger nails on the left hand, and was diagnosed as having Möbius' syndrome. Involvement of other cranial nerves such as three, four, five, nine, 10 and 12, and limb malformations may accompany this syndrome. However, several factors have been proposed for the etiology, some rare cases have also been reported with artificial reproductive technologies. Feeding difficulties and aspiration are the main problems encountered in infancy. The other cranial nerves should be examined further in newborns who present with congenital facial palsy, and other cranial dysinnervation disorders should be considered in the differential diagnosis.

Moebius Syndrome: An Updated Review of Literature

“…Moreover, there have been rare cases that report a link between the usage of artificial reproductive technologies such as in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ISCI) and the occurrence of Moebius Syndrome. 35 An interesting finding was made by Pederson et al, who, in a study on five Moebius Syndrome patients, reported that two patients were born to mothers with gynecological anomalies (unicornuate/ bicornuate uterus). 36 However, without conclusive information, it is impossible to state the exact etiology of Moebius Syndrome.…”

Pediatric Ptosis: A Review of Less Common Causes

“…It is sporadic, unlike the autosomal dominant pattern of inheritance of HCFP, and is considered a subset of congenital cranial dysinnervation disorders. 14 Moebius syndrome is nonprogressive and can be diagnosed early in life due to incomplete eyelid closure when asleep, poor suckling, and/or drooling. 11 Paralysis of the sixth cranial nerve is usually bilateral and complete.…”

“…Moebius syndrome, also known as Mobius syndrome, presents with congenital facial palsy along with impairment of the abducens nerve and/or other cranial nerves. It is sporadic, unlike the autosomal dominant pattern of inheritance of HCFP, and is considered a subset of congenital cranial dysinnervation disorders 14. Moebius syndrome is nonprogressive and can be diagnosed early in life due to incomplete eyelid closure when asleep, poor suckling, and/or drooling 11.…”

The challenging management of Moebius syndrome using orthodontic camouflage: A case report

“…MS is caused by unilateral/bilateral agenesis or aplasia of the facial (VII) and abducens (VI) cranial nerves 2,4 . Other nerves such as trigeminal (V), glossopharyngeal (IX), vagus (X), and/or hypoglossal nerve (XII) may also be involved 5,6 …”