Tylosin-urea adduct related to tylosin stability in cattle feed

Massey, Eddie H.; Dennen, David W.

doi:10.1021/jf60185a021

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“…TP (TYLAN| Premix, Elanco Products Company) is currently being marketed for various uses in swine and poultry feeds. TUA is formed by reacting tylosin with t/rea and it is more stable in the rumen than TP because of the incomplete hydrolysis of the adduct (Massey and Dennen, 1973). lfxperiment 1.…”

Section: Experimental Methodsmentioning

confidence: 99%

Tylosin Phosphate (TP) and Tylosin Urea adduct (TUA) for the Prevention of Liver Abscesses, Improved Weight Gains and Feed Efficiency in Feedlot Cattle

Brown

Elliston

McAskill

et al. 1973

Journal of Animal Science

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Four feedlot experiments with 774 cattle have been completed during 1969 to 1970 evaluating two forms of tylosin activity (50, 75 and 100 mg per head per day continuously of tylosin phosphate or tylosin urea adduct) in high concentrate rations. Continuous administration of these three levels of antibiotic activity from either form of tylosin (1) reduced the incidence of liver abscesses, (2) increased average daily gain, and (3) improved feed conversion of feedlot cattle. Mathematically combining data from all levels of both forms of tylosin demonstrated an 81.8% reduction (24.1% control vs. 4.2% treated)in incidence of liver abscesses (P < .01), a 5.9% increase (2.23 lb. [1.01 kg] control vs. 2.36 lb. [1.07 kg] treated) in average daily gain (P < .05) and a 3.1% improvement (7.65 control vs. 7.41 treated) in feed conversion (P < .10). Control cattle with normal livers gained 17.0 lb. (7.7 kg) more weight during the feeding period than control cattle with abscessed livers.

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Section: Experimental Methodsmentioning

confidence: 99%