Über 2,4‐Di‐(α‐pyridyl)‐thiazol

Abstract

Die Synthese des dem 2,6‐Di‐(α‐pyridyl)‐pyridin entsprechenden 2,4‐Di‐(α‐pyridyl)‐thiazols wird beschrieben.

The synthetic pathways to a family of pyridine-containing azoles - promising ligands for coordination chemistry

“…Thioamide is also obtained using a literature procedure, which includes catalytic hydrogen sulfide addition to nitrile 7. 19 We improved the known technique 20 in such a way, that the initially formed insoluble thiouronium salt is separated, and then coverted into the thiazole by quenching with triethylamine. In spite of low and moderate yields of 12, the total outcome for the thiazolylpyridine derivatives was significantly raised as compared to the work cited above.…”

“…The yields, melting points and spectral data of 9a-9d are presented in Tables 3,4. Typical procedure for the preparation of 2,4-dipyridylthiazoles 12a-12d 33 2-Bromo-1-pyridinylethanone (10a or 10b) (2.81 g, 10 mmol), pyridylcarbothioamide (11a or 11b) (1.38 g, 10mmol) and 50 ml of absolute ethanol were mixed in a 100 ml round-bottom flask. The resulting mixture was refluxed for 2h, then cooled and filtered.…”

New multidentate ligands for supramolecular coordination chemistry: double and triple helical complexes of ligands containing pyridyl and thiazolyl donor units

“…The key step in DALTON FULL PAPER every synthesis is assembly of the thiazole unit from reaction of an α-bromoacetyl group with a thioamide. The α-bromoacetyl group is simply prepared by bromination of an acetyl group, 13 and the thioamide is equally simply prepared by reaction of a cyano group with H 2 S. 12,14 Using this methodology allows, in principle, the preparation of a very wide variety of related ligands, as long as components bearing acetyl or cyano substituents are available as starting materials.…”

Synthesis of 3-Nitrosoimidazo[1,2-a]pyridine Derivatives as Potential Antiretroviral Agents

“…Chemical shifts are expressed from TMS using residual CHCl3 at δ 7.30 ppm, and from the central resonance of CDCl3 at δ 77.1 ppm. The following compounds were obtained according to described procedures: 2-phenylimidazo[1,2-a]pyridine 2a [16] , 8-methyl-2-phenylimidazo[1,2-a]pyridine 2b [17] , 7-methyl-2-phenylimidazo[1,2-a]pyridine 2c [17] , 6-methyl-2-phenylimidazo[1,2-a]pyridine 2d [17] , 8-benzyloxy-2-phenylimidazo[1,2-a]pyridine 2e [18] , 2-bromoacetylpyridine 3a [19] , 2-bromo-1-(naphth-2-yl)ethanone 3b [20] , 7-methyl-2-(biphen-4-yl)imidazo-[1,2-a]pyridine 4c [21] , 7-methyl-2-(thien-2-yl)imidazo[1,2-a]pyridine 4d [22] , 7-methyl-2-(fur-2-yl)imidazo[1,2-a]pyridine 4e [23] , 3-nitroso-2-phenylimidazo[1,2-a]pyridine 5 [24] , 7-methyl-3-nitroso-2-phenylimidazo[1,2-a]pyridine 7 [12] , and 8-benzyloxy-3-nitroso-2-phenylimidazo[1,2-a]pyridine 9 [25] . Original 1 H NMR for previously reported compounds are given in Table 2.…”