1907
DOI: 10.1002/cber.190704001156
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Über die Bedingungen der Fuselölbildung und über ihren Zusammenhang mit dem Eiweißaufbau der Hefe

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Cited by 274 publications
(143 citation statements)
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“…AA are important for the formation of higher alcohols such as propanol, isobutanol, and isoamyl alcohol via the Ehrlich pathway [38]. The AA are transaminated to α-keto acids and decarboxylated to form the respective aldehyde, which are further reduced to higher alcohols [10].…”
Section: Amino Acid Metabolismmentioning
confidence: 99%
“…AA are important for the formation of higher alcohols such as propanol, isobutanol, and isoamyl alcohol via the Ehrlich pathway [38]. The AA are transaminated to α-keto acids and decarboxylated to form the respective aldehyde, which are further reduced to higher alcohols [10].…”
Section: Amino Acid Metabolismmentioning
confidence: 99%
“…These aldehydes can be reduced to their corresponding branched alcohol (2-methyl-butanol, 3-methyl-butanol and 2-methyl-propanol) by action of the ADH enzyme, which uses NAD(P) + as a cofactor (30,140,143,145,147). The transformation of amino acids into alcohols is known as the Ehrlich pathway, in which the key enzymes are transaminases, decarboxylases and dehydrogenases (148). Branched aldehydes can also be oxidized to their corresponding branched fatt y acid (2-methyl-butanoic, 3-methyl-butanoic and 3-methyl-propanoic) by the action of aldehyde dehydrogenase (AldDH) (30,140,143,147), which uses NAD(P)H as a cofactor.…”
Section: Mcintoshmentioning
confidence: 99%
“…1. The Ehrlich pathway [3,4]. A schematic representation of the conversion of branched-chain amino acids to fusel alcohols; leucine via K-keto isocaproate and 3-methylbutyraldehyde to isoamyl alcohol; isoleucine via K-keto-L-methylvalerate and 2-methylbutyraldehyde to active amyl alcohol; valine via K-ketoisovalerate and isobutyraldehyde to isobutyl alcohol (valine: R = C 3 H 7 , leucine and isoleucine : R = C 4 H 7 ).…”
Section: Substrate Consumption and Formation Of Extracellularmentioning
confidence: 99%
“…In Saccharomyces cerevisiae fusel alcohols can be produced from the corresponding branched-chain amino acids via the Ehrlich pathway, involving an aminotransferase reaction (yielding the corresponding K-keto acids), a decarboxylation reaction (resulting in aldehyde formation), followed by reduction of aldehydes to fusel alcohols ( Fig. 1) [3,4]. Alternatively, the K-keto acids, synthesized as key intermediates in the respective amino acid biosynthetic pathways, may be directly converted into fusel alcohols.…”
Section: Introductionmentioning
confidence: 99%