Über Die Folgen Von Chordaexstirpation an Späten Gastrulae Und Neurulae Von Ambystoma Punctatum

Hörstadius, Sven

doi:10.1111/j.1463-6395.1944.tb00347.x

Cited by 30 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The notochord disruptions in Bcl-2-injected embryos are accompanied by defects in the neural tube and somites, with both tissues shorter than those in control embryos and corresponding to the length of the notochord. This is not surprising as it is well established that these tissues depend upon the notochord for their extension (Elul and Keller, 2000;Ezin et al, 2003;Horstadius, 1944;Jacobson, 1981;Kitchen, 1938;Kitchen, 1949;Nieuwkoop, 1947;Reverberi et al, 1960). However, signals from the notochord are also essential for the formation and patterning of the neural tube and somites (Fleming et al, 2001;Wilson and Maden, 2005).…”

Section: Discussionmentioning

confidence: 82%

“…For example, the lengthening of axial tissues such as the neural plate depends on notochord extension. Extirpation of the notochord reduces the elongation of the embryo in the regions where it is removed in amphibians (Horstadius, 1944;Kitchen, 1938;Kitchen, 1949;Nieuwkoop, 1947), chicks (Jacobson, 1981) and ascidians (Reverberi et al, 1960). In addition, convergent extension of the neural plate is weak unless it is explanted with notochord in Xenopus (Elul and Keller, 2000;Ezin et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Apoptosis regulates notochord development in Xenopus

Malikova

Stry

Symes

2007

Developmental Biology

View full text Add to dashboard Cite

The notochord is the defining characteristic of the chordate embryo and plays critical roles as a signaling center and as the primitive skeleton. In this study we show that early notochord development in Xenopus embryos is regulated by apoptosis. We find apoptotic cells in the notochord beginning at the neural groove stage and increasing in number as the embryo develops. These dying cells are distributed in an anterior to posterior pattern that is correlated with notochord extension through vacuolization. In axial mesoderm explants, inhibition of this apoptosis causes the length of the notochord to approximately double compared to controls. In embryos, however, inhibition of apoptosis decreases the length of the notochord and it is severely kinked. This kinking also spreads from the anterior with developmental stage such that, by the tadpole stage, the notochord lacks any recognizable structure, although notochord markers are expressed in a normal temporal pattern. Extension of the somites and neural plate mirrors that of the notochord in these embryos, and the somites are severely disorganized. These data indicate that apoptosis is required for normal notochord development during the formation of the anterior-posterior axis, and its role in this process is discussed.

show abstract