Über die katalytische Reduktion aliphatischer Carbonsäureamide

Guyer, A.; Bieler, A.; Gerliczy, G.

doi:10.1002/hlca.19550380641

Cited by 24 publications

(13 citation statements)

References 6 publications

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“…[6] Thea chievement of hydrogenation of amides under mild reaction conditions, ideally lower than 30 bar H 2 and 70 8 8C, [6] is listed as aleading candidate in 12 key innovative research areas for the future sustainable production of pharmaceuticals. [7] In early studies of the hydrogenation of amides,Co, [8] Ni, [9] Cu-Cr oxide, [10] and Re [11] catalysts were found to be effective, but required harsh reaction conditions,n amely 200-370 bar H 2 and 200-300 8 8C. In 1988, Dobson reported ac atalyst with much improved efficiency, namely abimetallic Pd/Re catalyst enabled amide hydrogenation at 130 bar H 2 and 200 8 8C.…”

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confidence: 99%

Mild Hydrogenation of Amides to Amines over a Platinum‐Vanadium Bimetallic Catalyst

et al. 2017

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Hydrogenation of amides to amines is an important reaction, but the need for high temperatures and H pressures is a problem. Catalysts that are effective under mild reaction conditions, that is, lower than 30 bar H and 70 °C, have not yet been reported. Here, the mild hydrogenation of amides was achieved for the first time by using a Pt-V bimetallic catalyst. Amide hydrogenation, at either 1 bar H at 70 °C or 5 bar H at room temperature was achieved using the bimetallic catalyst. The mild reaction conditions enable highly selective hydrogenation of various amides to the corresponding amines, while inhibiting arene hydrogenation. Catalyst characterization showed that the origin of the catalytic activity for the bimetallic catalyst is the oxophilic V-decorated Pt nanoparticles, which are 2 nm in diameter.

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confidence: 99%

Mild Hydrogenation of Amides to Amines over a Platinum‐Vanadium Bimetallic Catalyst

et al. 2017

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“…[4] Early efforts towards catalytic hydrogenation of amides with heterogeneous catalysts based on copper chromite, [5] rhenium, [6] and Raney catalysts [7] showed that the reaction is, in principle, feasible. [4] Early efforts towards catalytic hydrogenation of amides with heterogeneous catalysts based on copper chromite, [5] rhenium, [6] and Raney catalysts [7] showed that the reaction is, in principle, feasible.…”

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confidence: 99%

“…Unfortunately, the catalytic reduction of carboxylic acids and their derivatives is highly challenging, with amides being the least reactive motifs. [4] Early efforts towards catalytic hydrogenation of amides with heterogeneous catalysts based on copper chromite, [5] rhenium, [6] and Raney catalysts [7] showed that the reaction is, in principle, feasible. However, harsh reaction conditions, with temperatures of 175-260 8C and high pressures of 100-990 bar, were required in all cases.…”

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confidence: 99%

Catalytic Hydrogenation of Amides to Amines under Mild Conditions

2012

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“…Unfortunately, the catalytic reduction of carboxylic acids and their derivatives is highly challenging, with amides being the least reactive motifs 4. Early efforts towards catalytic hydrogenation of amides with heterogeneous catalysts based on copper chromite,5 rhenium,6 and Raney catalysts7 showed that the reaction is, in principle, feasible. However, harsh reaction conditions, with temperatures of 175–260 °C and high pressures of 100–990 bar, were required in all cases.…”

Section: Methodsmentioning

confidence: 99%