Über die Reaktionen von monosubstituierten Guanidinen mit 1-Phenyl-1,3-butandion

New 2-aminopyrimidine derivatives and their antitrypanosomal and antiplasmodial activities

“…Its melting point (201-205 °C) corresponded well with the reported one (202-204 °C) [18]. The synthesis of 4a was already described and the melting point (214 °C) corresponded well with the reported one (213 °C) [19].…”

New Strategies for the Synthesis of Pyrimidine Derivatives

“…[1,10] Whereas some of these methodologies employ the direct condensation of 1,3-dicarbonyl compounds with amidine derivatives, other reports describe multicomponent reactions to afford substituted pyrimidine derivatives. [1] Although the literature on pyrimidine synthesis enjoys a rich array of versatile methodologies, new convergent approaches remain valuable additions to the contemporary arsenal of synthetic strategies.…”

“…Representative synthesis of a pyrimidine by condensation of a N-C-N fragment and a diketone. [10] ments. Nitriles are a common N-C source and have been used to form pyrimidines in many syntheses.…”

“…Many of these prevailing strategies rely on condensation of N-C-N fragments, most often amidines or guanidines, with 1,3-dicarbonyl derivatives (Scheme 2). [1,10] Another versatile approach to pyrimidine synthesis utilizes N-C fragAbstract: Recent advances in pyrimidine synthesis are described. Modification of conventional strategies involving N-C-N fragment condensation with 1,3-dicarbonyl derivatives remains a common theme in current literature.…”

An efficient one‐pot synthesis of 2‐aminopyrimidinomethylnaphtols under solvent‐free conditions

“…On the other hand, pyrimidine and their derivatives, a type of important N‐containing heteroaromatic scaffolds, are recognized as extremely important heterocycles in bioorganic and medicinal chemistry because of their biological properties and therapeutic importance . 2‐Aminopyrimidine compounds were synthesized, and many derivatives have been found to be clinically active molecules that exhibit antitumor (Meridianins) and antimicrobial properties (Diaveridine), decrease the cholesterol level (Rosuvastatin), and aid in the treatment of anemia (Peroyl‐ l ‐glutamic) . Because of the abovementioned properties of aminopyrimidins, as a part of our ongoing program on MCRs, here, we report an eco‐friendly, simple, and efficient method for the synthesis of 2‐aminopyrimidinomethylnaphtol compounds via a one‐pot three‐component reaction using 2‐naphthol, 2‐aminopyrimidine, and aromatic aldehydes in the presence of MgSO 4 ·3H 2 O under solvent‐free conditions (Scheme ).…”