Über eisenhaltige Wachstumsfaktoren, die Sideramine, und ihre Antagonisten, die eisenhaltigen Antibiotika Sideromycine

The Role of Iron in Bacterial Infections, with Special Consideration of Host-Tubercle Bacillus Interaction

“…The great majority of baeterial species (autosequesteric) produce sideramines (BICKEL et al, 1960;BURNHAM, 1963) which faeilitate the transport of iron into the microbial celI. A few bacterial species (anautosequesterie) are unable to synthesize their own sideramine and, unIess supplied with such a material, eannot grow even in the presence of available iron.…”

The Treatment of Haemochromatosis with Desferrioxamine

“…Ferrioxamine was prepared in a pure condition, defined, and synthesised in the Research Laboratories of CIBA, Basle (1,2,10).…”

Investigations on the Action of the Iron-Containing Growth Factors, Sideramines; and Iron-Containing Antibiotics, Sideromycins

“…During the last 10 years a series of naturally occurring iron-binding compounds possessing potent biological activity has been discovered (Hesseltine et al 1952 ;Neilands, 1952; Lochhead, Burton & Thexton, 1952; Bickel et al 1960). The only feature common to all these compounds is that the iron-binding structure is in each case a secondary hydroxamic acid (Emery & Neilands, 1959; Bickel et al 1960).…”

“…The only feature common to all these compounds is that the iron-binding structure is in each case a secondary hydroxamic acid (Emery & Neilands, 1959; Bickel et al 1960). Biologically the compounds seem to fall into two groups: growth factors and antibiotics.…”

“…Bickel and co-workers have observed that with certain bacteria these ironcontaining antibiotics and iron-containing growth factors are mutually antagonistic (Bickel et al 1960;Zahner, Hutter & Bachmann, 1960). They proposed the generic name siderochrome to include all naturally occurring iron-binding hydroxamic acids.…”