Über krystallinisches männliches Hormon aus Hoden (Testosteron), wirksamer als aus Harn oder aus Cholesterin bereitetes Androsteron.

David, K.; Dingemanse, E.; Freud, J.; Laqueur, Ernst

doi:10.1515/bchm2.1935.233.5-6.281

Cited by 298 publications

(57 citation statements)

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“…Shortly after the elucidation of routes enabling the chemical synthesis of testosterone (Butenandt & Hanisch, 1935;David et al, 1935;Ruzicka & . ESI product ion spectra of protonated molecules (M þ H) þ of (a) 5a-androstan-17b-ol-3-one, (b) testosterone, and (c) 19-nortestosterone.…”

Section: Anabolic-androgenic Steroidsmentioning

confidence: 99%

Mass spectrometry in sports drug testing: Structure characterization and analytical assays

Thevis

Schänzer

2006

Mass Spectrometry Reviews

177

128

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Owing to the sensitive, selective, and unambiguous nature of mass spectrometric analyses, chromatographic techniques interfaced to various kinds of mass spectrometers have become the most frequently employed strategy in the fight against doping. To obtain utmost confidence in analytical assays, mass spectrometric characterization of target analytes and typical dissociation pathways have been utilized as basis for the development of reliable and robust screening as well as confirmation procedures. Methods for qualitative and/or quantitative determinations of prohibited low and high molecular weight drugs have been established in doping control laboratories preferably employing gas or liquid chromatography combined with electron, chemical, or atmospheric pressure ionization followed by analyses using quadrupole, ion trap, linear ion trap, or hyphenated techniques. The versatility of modern mass spectrometers enable specific as well as comprehensive measurements allowing sports drug testing laboratories to determine the misuse of therapeutics such as anabolic-androgenic steroids, stimulants, masking agents or so-called designer drugs in athletes' blood or urine specimens, and a selection of recent developments is summarized in this review.

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Section: Anabolic-androgenic Steroidsmentioning

confidence: 99%

Mass spectrometry in sports drug testing: Structure characterization and analytical assays

Thevis

Schänzer

2006

Mass Spectrometry Reviews

177

128

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“…This was signified by the 1935 virtual deadheated race between three industrial scientific groups, crowned by Nobel Prize recognition for two but curiously not the third, to fully characterize the major mammalian male hormone, which came to be named testosterone. [7][8][9] Hope never springs eternal more, it seems, than when it comes to rejuvenation.…”

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confidence: 99%

An old emperor finds new clothing: rejuvenation in our time

Handelsman

2010

Asian J Androl

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“…On the androgen front, Butenandt & Tschering (1934) isolated 15 mg of a hormonal substance they named androsterone from 15,000 liters of male urine. Androsterone proved to be a weak metabolite of the main testicular androgen, testosterone, which was isolated from bull testes by Ernst Lacquer (David et al 1935) and simultaneously synthesized by Ruzicka & Wettstein (1935). Butenandt & Westphal (1935) also achieved isolation of the 'second' female sex steroid, progesterone -the hormone of pregnancy -from pig ovaries.…”

Section: Raging Hormonesmentioning

confidence: 99%

On gonads and gadflies: the estrus angle

Hillier

2017

Journal of Endocrinology

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The first sex steroid to be crystallized was the vertebrate ovarian hormone, estrone -a less potent metabolite of 17β-estradiol, which in mammals stimulates the female urge to mate (estrus). The gadfly (Greek oistros) lent its name to the process of estrus, as an insect that bites and torments in classical Greek mythology. With the purification and crystallization of a moult-inducing steroid (ecdysone) from insects, an interesting parallel emerged between mating and moulting in lower mammals and arthropods. Ecdysterone (potent ecdysone metabolite) has anabolic effects in mammalian muscle cells that can be blocked by selective estrogen receptor antagonists. Insects utilize ecdysteroids in similar ways that vertebrates use estrogens, including stimulation of oocyte growth and maturation. Ecdysteroids also modify precopulatory insect mating behaviour, further reinforcing the gonad-gadfly/mate-moult analogy.

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Über krystallinisches männliches Hormon aus Hoden (Testosteron), wirksamer als aus Harn oder aus Cholesterin bereitetes Androsteron.

Cited by 298 publications

References 0 publications

Mass spectrometry in sports drug testing: Structure characterization and analytical assays

Mass spectrometry in sports drug testing: Structure characterization and analytical assays

An old emperor finds new clothing: rejuvenation in our time

On gonads and gadflies: the estrus angle

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