Über Veränderungen des Mesenchymstoffwechsels durch Umweltfaktoren, durch Hormone und bei rheumatischen Erkrankungen

Hauss, W. H.; Junge-Hülsing, G; Gerlach, U; Wirth, W.

doi:10.1007/978-3-642-45798-2_4

Cited by 15 publications

(3 citation statements)

References 39 publications

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“…An increase of mucopolysaccharides outside the area of inflammation is brought about by polynuclears and macrophages (HAuSS and JUN~-HuLS~N~ [3]). According the assumption of D~LAUNAY [2] these compounds would play a role in the genesis of fibrils.…”

Section: In Vivo Actionmentioning

confidence: 98%

Histamine and 5-hydroxytryptamine uptake by some mucopolysaccharides

1973

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Various experiments in vitro (dialysis equilibrium, pharmacological action on the guinea-pig ileum, chromatography in Sephadex columns) and in vivo (studies on the bronchospasm of the guinea-pig) lead to the conclusion of a fixation of histamine by the sulfuric ester of pentosan. The activity of this product on the bronehospasm by serotonin has also been demonstrated. The biochemical properties of this substance lead to a decrease of the pharmacologic alactivity of histamine and serotonin, known to be involved in inflammatory reactions.Histamine and 5-hydroxytryptamine play an important role in allergic diseases and in inflammation. But histamine, may be, is active only during the initial stages of the acute inflammatory reaction participating mainly in vascular manifestations.The evidence of such a role is given by the complete disappearance of these vascular manifestations by the simultaneous actions of mepyramine on HI receptors and burimamide on H2 receptors.To preyent early manifestations of inflammation, it is necessary to decrease the toxicity of histamine and also that of 5-hydroxytryptamine.Our experiments have shown that many large molecules, such as mucopolysaccharides, bind histamine. First, it was shown that mucine (PARROT [6]) in the gut binds histamine and that is why the guinea-pig is almost insensitive to orally given histamine. In 1951, we could show by equilibrium dialysis that heparin is able to bind in vitro. In the same year we observed that serum bound part of added histamine, and finally it was found that the compound responsine for this phenomenon was a mucopolysaccharide which we called plasmapexine I.

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Section: In Vivo Actionmentioning

confidence: 98%

Histamine and 5-hydroxytryptamine uptake by some mucopolysaccharides

1973

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“…including col lagen, as part of a 'nonspecific mesenchymal reaction' [3], Our experi ments showed that phenylbutazone had an inhibitory effect on the early phases of collagen metabolism in normal animals. This effect of phenyl butazone would probably be manifested in a much more pronounced man ner under conditions involving an increase in the rate of collagen metab olism (rheumatoid arthritis, fibro-proliferative inflammation).…”

Section: Discussionmentioning

confidence: 91%

The Influence of Phenylbutazone on Collagen Metabolism in vivo

Trnavskỳ¹,

Trnavská²

1971

Pharmacology

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The effect of phenylbutazone in daily doses of 100 mg/kg on collagen metabolism in rats was studied after an injection of ¹⁴C-proline, by determining specificand total ¹⁴C-hydroxyproline activity in the skin collagen fractions and urine. It was found that a 21-day administration of phenylbutazone influenced the earlyphases of collagen metabolism by inhibiting collagen biosynthesis. The later phases of collagen turnover (maturation) were not affected by phenylbutazone treatment. In the given dose, phenylbutazone did not stimulate the catabolism of either newly-formed, soluble collagen, or mature, insoluble collagen.

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“…of S35 ChS and in the other 12 fiC of S35-methionine/100 g b.w. 48 h prior to being sacrificed at 0, 6,8,10,12,14,20 and 25 days after the injection of Carrageenin. The weight of the granuloma, its hydroxy-N em e th -C s6 k a , Uptake of S35-Methionine and S35-Chondroitin proline content, as well as the specific radioactivity of the serum, exudate, liver, spleen and pancreas were measured.…”

Section: Methodsmentioning

confidence: 99%

Uptake of S35-Methionine and S35-Chondroitin Sulphate by the Carrageenin Granuloma in Rats of Different Ages

Németh-Csóka¹

1966

Gerontology

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Über Veränderungen des Mesenchymstoffwechsels durch Umweltfaktoren, durch Hormone und bei rheumatischen Erkrankungen

Cited by 15 publications

References 39 publications

Histamine and 5-hydroxytryptamine uptake by some mucopolysaccharides

Histamine and 5-hydroxytryptamine uptake by some mucopolysaccharides

The Influence of Phenylbutazone on Collagen Metabolism <i>in vivo</i>

Uptake of S<sup>35</sup>-Methionine and S<sup>35</sup>-Chondroitin Sulphate by the Carrageenin Granuloma in Rats of Different Ages

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