Ubiquitous Expression of Selenoprotein N Transcripts in Chicken Tissues and Early Developmental Expression Pattern in Skeletal Muscles

Zhang, Jiuli; Li, Jinlong; Zhang, Ziwei; Sun, Beicheng; Wang, Rihua; Jiang, Zhihui; Li, Shu; Xu, Shiwen

doi:10.1007/s12011-011-9249-9

Cited by 12 publications

(3 citation statements)

References 21 publications

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“…Different levels of expression were observed in the brain, liver, spleen, testis, thyroid, as well as in cardiac and skeletal muscles [ 11 ]. Selenoproteins, such as GPX s, were found to express in the liver, kidney, and muscle [ 5 ], whereas SELW and SELN mRNA transcripts were detected in various kinds of tissues, especially more abundant in muscles [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs

Juszczuk-Kubiak

Bujko

Cymer

et al. 2015

Biol Trace Elem Res

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Effect of selenium (Se) supplementation on the selenoprotein and lipid metabolism gene expression patterns in ruminants, especially in lambs is not yet fully understood. The aim of study was to evaluate the effect of Se supplementation on the messenger RNA (mRNA) expression patterns of selected selenoproteins and genes related to lipid metabolism in growing lambs. The experiment was conducted on 48 Polish Merino lambs divided into two groups (n = 24): control (C)—lambs fed with a basal diet (BD) with no Se supplementation, and supplemented (S)—lambs fed with a BD, supplemented with 0.5 mg Se/kg as sodium selenate for 8 weeks. Expression of 12 selenoproteins and six genes related to lipid metabolism was analyzed in the liver and longissimus dorsi (LD) muscle of growing lambs by qPCR. Significant differences were found in the expression of GPX1, GPX2, SEPM, SEPW1, SEP15, SEPGS2, and TXNRD1 in the liver, and GPX1, SEPP1, SEPN1, SEPW1, SEP15, and MSRB1 in the LD muscle between S and C lambs. Se supplementation mainly upregulated SEPW1, SEP15 (P < 0.001; P < 0.01) mRNA expression in the liver, and GPX1, SEPP1, SEPN1, SEPW1 (P < 0.001; P < 0.01) in the muscle of S group. On the other hand, significant decrease in GPX2 (P < 0.01), SEPM (P < 0.001), and SEPHS2 (P < 0.01) mRNA expression levels were observed in the liver of S group of lambs. Se supplementation did not affect PON1, LXRα, and PPARα mRNA expression levels, but a significant increase in mRNA levels of APOE and LPL in the LD muscle (P < 0.05) as well as LPL (P < 0.05) in the liver were noticed in the group of Se supplemented lambs. Our study confirmed that, in lambs, similarly to other species, mRNA expression patterns of several selenoproteins highly depend on dietary Se levels, and their expression is ruled by hierarchical principles and tissue-specific mechanisms. Moreover, the study showed that changes Se intake leads to different levels of genes expression related with lipid metabolism.

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Section: Introductionmentioning

confidence: 99%

Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs

Juszczuk-Kubiak

Bujko

Cymer

et al. 2015

Biol Trace Elem Res

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“…However, this additional exon 3 appeared to be primate specific and later analyses indicated that the second isoform, in which exon 3 is spliced out, is the most abundant in cells and the only one to be translated into protein (Petit et al 2003). Screening for SELENON mRNA revealed its expression in many tissues, including skeletal and cardiac muscles, though at different levels (Lescure et al 1999;Castets et al 2009;Zhang et al 2012).…”

Section: Molecular Description Of Selenon Gene and Protein: Expressio...mentioning

confidence: 99%

Uncovering the Importance of Selenium in Muscle Disease

Lescure

Baltzinger

Zito

2018

Molecular and Integrative Toxicology

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A connection between selenium bioavailability and development of muscular disorders both in humans and livestock has been established for a long time. With the development of genomics, the function of several selenoproteins was shown to be involved in muscle activity, including SELENON, which was linked to an inherited form of myopathy. Development of animal models has helped to dissect the physiological dysfunction due to mutation in the SELENON gene; however the molecular activity remains elusive and only recent analysis using both in vivo and in vitro experiment provided hints toward its function in oxidative stress defence and calcium transport control. This review sets out to summarise most recent findings for the importance of selenium in muscle function and the contribution of this information to the design of strategies to cure the diseases.

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“…Suboptimal selenoprotein levels upregulate inflammatory cytokines [ 24 ], leading to muscle weakness and oxidative damage [ 25 ]; higher levels of interleukin 6 (IL-6) have been associated with low selenium status [ 26 , 27 ]. IL-6 can impact muscle function and contraction as it interferes with insulin-like growth factor 1 (IGF-1) secretion [ 28 , 29 , 30 ] and is also involved in bone resorption and receptor activator of nuclear factor kappa-Β ligand (RANK-L) signalling [ 31 , 32 , 33 , 34 ]. Likewise, muscle function can be impaired; selenium-deficient patients had elevated levels of serum creatine kinase, muscle fatigue, pain, and proximal weakness [ 2 , 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Selenium Intakes and Musculoskeletal Function in Very Old Adults: Analysis of the Newcastle 85+ Study

et al. 2020

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Background: Selenium is a trace element essential for health. Severe selenium deficiencies are associated with poor musculoskeletal (MSK) function. However, the effects of moderate deficiency on MSK function, especially in older adults, is unclear. Objectives: To determine the associations between selenium intake and MSK function in very old adults. Methods: Selenium intake at baseline and, hand-grip strength (HGS) and timed-up-and-go (TUG) at four phases over 5 years, were available in 791 participants in the Newcastle 85+ Study, a community-based, longitudinal cohort of ≥85 year old individuals. We investigated relationships between selenium intake and HGS and TUG in cross-sectional analyses at baseline using multivariate analyses and, prospectively using linear mixed models to explore HGS and TUG changes over 5 years in association with baseline selenium intake. Results: At baseline, 53% of participants had selenium intakes that were classified as low. These individuals had 2.80 kg lower HGS and were 2.30 s slower performing the TUG, cross-sectionally. In multivariate, baseline analyses, selenium intake had no significant impact on HGS or TUG. Selenium intake had no significant effect on MSK function, prospectively. Conclusion: Low selenium intake is common among very old adults and, in cross-sectional analyses, is associated with poorer MSK function.

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Ubiquitous Expression of Selenoprotein N Transcripts in Chicken Tissues and Early Developmental Expression Pattern in Skeletal Muscles

Cited by 12 publications

References 21 publications

Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs

Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs

Uncovering the Importance of Selenium in Muscle Disease

Dietary Selenium Intakes and Musculoskeletal Function in Very Old Adults: Analysis of the Newcastle 85+ Study

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