Uji Daya Hambat dan Toksisitas Ekstrak Daun Jamblang [Syzygium cumini (L.) Skeels] Terhadap Pertumbuhan Bakteri Staphylococcus epidermidis

Rachmawati, Nurmeily; Maulidiyah, Gina; Aminah,

doi:10.47349/jbi/17012021/39

Cited by 4 publications

(7 citation statements)

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“…Darajat stated that the higher the concentration of antibacterial substances, the more antibacterial compounds contained, which means bacteria will be killed quickly at higher concentrations. 25 In this study, bacterial growth was found at each concentration of 2%, 4%, and 8%, and several technical and biological factors could cause this in the control group. The technical factors can mainly be controlled by researchers; these include the large inoculum, pH, incubation length, temperature, and medium.…”

Section: Discussionmentioning

confidence: 63%

Inhibitory test of andaliman (Zanthoxylum achantopodium DC) extract mouthwash against dental plaque bacteria

et al. 2023

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Background: Andaliman (Zanthoxylum achantopodium DC) is an endemic plant that is found in the province of Sumatera Utara, Indonesia. It contains secondary metabolites, such as alkaloids, flavonoids, glycosides, saponins, tannins, and triterpenoids/steroids, which can potentially be used as a mouthwash. Streptococcus sanguinis and Staphylococcus aureus are the primary colonizing bacteria in plaque formation. Bacterial plaque is known to be the main cause of periodontal disease but can be controlled mechanically and chemically using mouthwash. Purpose: To determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of andaliman extract mouthwash (2%, 4%, 8%) against Streptococcus sanguinis ATCC®10556™ and Staphylococcus aureus ATCC® 25923™. Methods: This is a laboratory study with a post-test control-only design. The sample consists of andaliman extract mouthwash (2%, 4%, 8%), a positive control (chlorhexidine gluconate 0.2%), and a negative control (mouthwash formulation without andaliman extract) with three repetitions for each group. Data were analyzed with the one-way ANOVA test and post hoc LSD test. Results: The andaliman extract mouthwash with concentrations of 2%, 4%, and 8% significantly reduced the number of Streptococcus sanguinis and Staphylococcus aureus colonies (p<0.05), and there was a significant difference in the andaliman extract mouthwash with concentrations of 2%, 4%, and 8% compared to the negative control. Conclusion: Andaliman extract mouthwash with a concentration of 8% was more effective in inhibiting Streptococcus sanguinis growth than Staphylococcus aureus. The MIC values for both bacteria were 2%, but the study could not determine the MBC value.

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Section: Discussionmentioning

confidence: 63%

Inhibitory test of andaliman (Zanthoxylum achantopodium DC) extract mouthwash against dental plaque bacteria

et al. 2023

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“…LC50 value of forest chili leaf extract in this study was 0.26027% or 2603 ppm. Rachmawati et al (2021) conducted research on the toxicity of jamblang leaf extract (Syzygium cumini (L.) Skeels) on the growth of S. epidermidis bacteria using the Brine Shrimp Lethality Test (BSLT) method. The LC50 value of jamblang leaf extract was found, namely at a concentration of 485.5 ppm.…”

Section: Growth Parametersmentioning

confidence: 99%

“…The LC50 value of jamblang leaf extract was found, namely at a concentration of 485.5 ppm. If the LC50 value is below 1000 ppm or 0.1%, then the plant extract can be declared toxic (Rachmawati et al, 2021). Based on this, the forest chili leaf extract can be said to be non-toxic.…”

Section: Growth Parametersmentioning

confidence: 99%

Antibacterial Activity and Preliminary Phytochemical Screening of Forest Chili Leaf (Piper caninum Bl.) Ethanol Extract against Staphylococcus epidermidis

Shanzet,

Darmayasa,

Suriani

et al. 2024

TPJ

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Forest chili leaves (Piper caninum Bl.) has a potential to become an alternative to conventional antibiotics. This study aims to determine the Minimum Inhibitory Concentration (MIC) of forest chili leaf extract, assess the Lethal Concentration (LC50), and analyze the phytochemical composition of the extract. This study also conducted a Completely Randomized Design (CRD) with four repetitions. The agar well diffusion method is used in this study with various concentrations such as T1 ethanol 96% (negative control), T2 (5% concentration), T3 (10% concentration), T4 (15% concentration), T5 (20% concentration), T6 (25% concentration), and T7 Ciprofloxacin 1% (positive control). Data were subjected to ANOVA at a significance level of 5% and further analyzed using Duncan's test. The results showed that all concentrations of forest chili leaf extract (P. caninum Bl.) exerted a statistically significant effect (P 0.05) against Staphylococcus epidermidis bacteria. The research found that the most effective concentration to inhibits S. epidermidis is at 25%, which generates an inhibitory zone of 25.38 ± 0.52 mm. The estimated MIC value for forest chili leaf extract against S. epidermidis was found to be 0.2%, producing an inhibitory zone of 6.38 ± 0.32 mm. Additionally, the calculated LC50 value was 0.26%. Phytochemical screening revealed the presence of various bioactive compound groups in the forest chili leaf extract, including alkaloids, flavonoids, phenols, tannins, and steroids.

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“…Likewise, research using herbs in the form of cashew leaf extract as much as 1% in feed significantly increased the intestinal surface area, intestinal length and the number of goblet cells in the digestive tract of Javanese chickens [9]. The antioxidant content in herbal extracts is able to stimulate an increase in the number of goblet gland cells, protect the intestinal mucosa, so that nutrient absorption can occur optimally [1]. The anti-1183 (2023) 012022 IOP Publishing doi:10.1088/1755-1315/1183/1/012022 4 inflammatory content in jamblang leaf extract is able to maintain the surface of the intestine, so that the intestinal condition becomes healthy.…”

Section: Effect Of Jamblang Leaf Extract In Drinking Water On Intesti...mentioning

confidence: 99%

“…Additives derived from herbs contain various benefits, including as antioxidants and antimicrobial pathogens. The ethanol extract of jamblang leaves contains flavonoids, tannins, saponins, and steroids with a total flavonoid content of 1.38% and the toxicity test produces an IC50 value of 485.50 ppm which indicates the jamblang plant extract is toxic [1]. The difference in the jamblang leaf extract method causes differences in the phenolic substances obtained, the cold extraction method (maceration) produces a lower percentage of phenol than the hot method (reflux) with a phenol percentage value of 44.21% [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of jamblang leaf in drinking water on physical quality, lactic acid bacteria population and intestinal villi histology of broiler chickens

Allaily

Wajizah

Wahyudi

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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This research was conducted aiming to find alternative antibiotics using local plants that are rich in antioxidants. The antioxidant content in plants is used as a feed additive and as an alternative to antibiotics, so that livestock products are safe from antibiotic residues. Jamblang leaf is one of the potential typical plants in Aceh which is expected to be used as an alternative to antibiotics in broiler cultivation. The study used 4 treatments of jamblang extract given into drinking water. P0 used drinking water without jamblang extract, P1 used 0.25 g/L drinking water, P2 used 0.5 g/L drinking water, P3 used 1 g/L drinking water. The study used a completely randomized design (CRD) with 4 treatments and each treatment was repeated 3 times with a total of 5 chickens per replication. The parameters measured were the physical quality of the intestinal villi (height of the intestinal villi, lumen thickness and number of glands), the population of lactic acid bacteria (LAB) in the digestive tract, and the histological condition of the intestinal villi of broiler chickens. Data were analyzed using analysis of variance. The results showed that the treatment had no significant effect (P>0.05) on the physical quality of the intestinal villi, but the treatment significantly (P<0.05) decreased the LAB population in the P2 treatment. The condition of the intestinal villi due to the treatment still stood upright compared to the control. In conclusion, jamblang extract given into drinking water has not been able to improve the physical appearance of the intestinal villi and tends to reduce the LAB population in the intestinal tract.

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Uji Daya Hambat dan Toksisitas Ekstrak Daun Jamblang [Syzygium cumini (L.) Skeels] Terhadap Pertumbuhan Bakteri Staphylococcus epidermidis

Cited by 4 publications

References 0 publications

Inhibitory test of andaliman (Zanthoxylum achantopodium DC) extract mouthwash against dental plaque bacteria

Inhibitory test of andaliman (Zanthoxylum achantopodium DC) extract mouthwash against dental plaque bacteria

Antibacterial Activity and Preliminary Phytochemical Screening of Forest Chili Leaf (Piper caninum Bl.) Ethanol Extract against Staphylococcus epidermidis

Effect of jamblang leaf in drinking water on physical quality, lactic acid bacteria population and intestinal villi histology of broiler chickens

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