Uji efektivitas gel ekstrak etanol daun kelor (Moringa oleifera L.)  sebagai antijamur Malassezia furfur

Yusuf, Anna L; Nurawaliah, Ecin; Harun, Nurhidayati

doi:10.26874/kjif.v5i2.119

Cited by 23 publications

(29 citation statements)

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“…Although all formulations have low viscosity, most formulations still have good adhesivity. Topical formulations were considered to have good spreadability if the diameter of the circle after spreading of the gel is in the range of 5 to 7 cm, and good adhesivity if the time required for separating two slides with formulation placed in between them is more than 1 second (Garg et al, 2002;Nurman et al, 2019;Yusuf et al, 2017). To evaluate the effect of variability of PEG 400 and propylene glycol on all parameters, data listed in Table 2 were subjected to analysis of the best-fitted model, polynomial equation, and contour plot using Design-Expert software version 10.0.3.…”

Section: Results and Discussion Optimization Of Peg 400 And Propylene...mentioning

confidence: 99%

Development and optimization of Curcuma longa Linn. oleoresin non-aqueous gel for transdermal delivery

Arimurni¹,

S²,

Colatama³

2022

Pharmaciana

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A long-term oral administration of NSAID and DMARD on rheumatoid arthritis (RA) treatment may cause gastritis, kidney, and cardiovascular disorder. One of the alternative therapies that have been investigated is by using herbal medicine such as Curcuma longa Linn. which contains curcumin and essential oils. Even though both compounds are quite effective in treating RA, poor aqueous solubility and low intestinal absorption limit their oral bioavailability. To overcome these drawbacks, transdermal delivery was chosen as an alternative route of administration. This study was aimed to formulate the Curcuma longa Linn. oleoresin into a transdermal non-aqueous gel system using Carbopol 934 and low substituted hydroxypropyl cellulose (4.25:0.75 %) as the gelling agent. In this study, multiple solvents (PEG 400, PG, glycerin, ethanol, and tween 20) were used in the system. The solvents were chosen based on their ability to dissolve the gelling agents. Optimization was done using a simplex lattice design based on the physical characteristics (viscosity, pH, spreadability, and adhesivity) of the prepared gel. The system with the optimum concentration of PEG 400 and PG was then observed for its stability and in vitro transport through snakeskin membrane using Franz diffusion cell with PBS pH 7.4 as acceptor medium. The optimal formula was comprised of 75% PEG and 25% PG which has a viscosity of 6.34+0.19 dPa.s, adhesivity of 6.05+0.11 seconds, pH of 5.16+0.09, spreadability of 6.94+0.06 cm, and quite stable after freeze-thaw cycling test, whilst around 26.85% curcumin was diffused through the membrane (flux = 0.084 mg.cm -2 ) after 2 hours. It can be concluded that the Curcuma longa Linn. oleoresin can be formulated into a non-aqueous gel system, which showed a fair gel physical characteristic with good stability and ability to permeate across the skin membrane, and is promising to be further developed as an alternative for RA treatment.

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Section: Results and Discussion Optimization Of Peg 400 And Propylene...mentioning

confidence: 99%

Development and optimization of Curcuma longa Linn. oleoresin non-aqueous gel for transdermal delivery

Arimurni¹,

S²,

Colatama³

2022

Pharmaciana

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“…Then covered with glass as the initial load and allowed to stand for 1 minute. After 1 minute the dispersion diameter was measured for each additional 50 g of weight up to 150 g. The gel satisfies the requirement if this diameter is in the range of 5-7 cm (Yusuf et al, 2017).…”

Section: Spreadability Testingmentioning

confidence: 99%

“…Adhesion was determined from the time it took for the two slides to come off. The standard requires that the said time should be longer than 4 seconds (Yusuf et al, 2017).…”

Section: Adhesion Testingmentioning

confidence: 99%

Burn wound healing activity of ethanol extract gel of Green Algae (Ulva lactuca L) in mice

et al. 2022

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Recently, burn injuries have become a major cause of morbidity and mortality in low-middleincome countries. Burn injuries are tissue loss caused by contact with heat sources such as hot water, fire, chemicals, electricity, and radiation. According to the WHO Global Burden Disease, in 2017 an estimated 180.000 people died from burn injuries. Ethanol extract of green algae (EEGA) contains compounds that potentially heal burn injuries. The research was conducted to obtain a gel formulation from EEGA and test its burn wound healing properties in mice (Mus musculus). Forty-five mice were divided into five groups: I (negative control), II (treated with gel base), III (positive control, Bioplacenton gel), IV (5% EEGA gel), and V (10% EEGA gel). Wound diameters and description scores were observed every fourth, seventh, and fourteenth day, and the derived data were analyzed in the SPSS program with the one-way analysis of variance (ANOVA) and least significance difference (LSD) test. The results indicate that EEGA can be formulated into gels with physical properties compliant with the requirements of the dosage form. Further, it was found that Groups IV and V showed significant reductions in wound description scores and diameters (p<0.05). In conclusion, gels containing 5% and 10% EEGA possess burn wound healing properties.

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“…Cara menentukan kelengketan adalah waktu yang dibutuhkan dua slide untuk lepas. Persyaratan daya lekat yang sesuai lebih dari 1 detik [20].…”

Section: Uji Daya Lekatunclassified

“…Untuk mengukur diameter sebaran formulasi, dilakukan pengukuran pada arah membujur dan melintang, dengan setiap penambahan beban 50 gram, hingga berat totalnya menjadi 150 gram. Daya sebar yang memnuhi standar adalah 5-7 cm [20].…”

Section: Uji Daya Sebarunclassified

Formulation and Evaluation of Physical Stability Natural Acne Gel Based on Aloevera Gel with Essential Oil Blend

Nurlaila

Rachmadani

Harismah

2022

UJAS

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This study aims to determine the formulation and evaluation of natural acne gel preparations made from aloe vera gel with a mixture of essential oils where the concentration of aloe vera gel can affect the stability of natural acne gel preparations. The use of herbal cosmetics is preferred because it comes from natural ingredients, is safe, can be used by all skin types, has various choices, is inexpensive, has low side effects, and does not pollute the environment. Organoleptic Test Process, pH Test, Adhesion Test, Spreadability Test, Stability Test (Cycling Test) for evaluation of natural acne gel preparations. The results showed that the higher the concentration of aloe vera gel, the higher the pH, dispersion, and stability. By paying attention to the data from each formula, it can be concluded that the most optimal preparation is the F3 preparation which shows the appropriate pH results, appropriate dispersion and homogeneous stability.

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Uji efektivitas gel ekstrak etanol daun kelor (Moringa oleifera L.) sebagai antijamur Malassezia furfur

Cited by 23 publications

References 0 publications

Development and optimization of Curcuma longa Linn. oleoresin non-aqueous gel for transdermal delivery

Development and optimization of Curcuma longa Linn. oleoresin non-aqueous gel for transdermal delivery

Burn wound healing activity of ethanol extract gel of Green Algae (Ulva lactuca L) in mice

Formulation and Evaluation of Physical Stability Natural Acne Gel Based on Aloevera Gel with Essential Oil Blend

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