Based on a historical overview of spatial networks and mobility, and the development of spatial theory, this review discusses current rural problems in Europe and the need for a new rural policy. The development toward a post-urban world, that is, a world where the traditional urban-rural dichotomy is dissolving and is replaced by city-regions and vast, declining peripheries, means a division of rural areas into two types: those becoming integrated into the growing city-regions and the peripheries, where exploitation of natural resources is a main activity. We claim that a policy that only focuses on rural areas would fail. The reason is that endogenous rural development is simply not possible in current Europe. What is required is better urban-rural development policies oriented towards maximizing the development potential of each region, combining peoplebased with place-based approaches, and empowering local stakeholders to take greater control of their future. Regional science has an important role to play in providing decisionmakers with evidence-based research that meets the challenges of the post-urban world.