Ulcerative Lesions of the Mouth: An Update for the General Medical Practitioner

Abstract

Leão JC, Gomes VB, Porter S. Ulcerative lesions of the mouth: an update for the general medical practitioner. Clinics. 2007;62(6):769-80.Oral ulceration is a common complaint of patients attending out-patient clinics. Because of the diversity in causes of oral ulceration, patients presenting with oral mucosal disease can be challenging to diagnose and manage. Patients with signs or symptoms of oral ulcers are sometimes referred to gastroenterology clinics; however, in most instances the ulcers do not result from gastrointestinal disease. The aim of the present article is to review aspects of the etiology, diagnosis and management of common ulcerative disorders of the oral mucosa. A search in the National Library of Medicine computerized bibliographic database MEDLINE was performed. Selection of publications, extraction of data, and validity assessment were then performed by the authors. Based upon the searched literature, it is concluded that there are several systemic disorders that can present with similar clinical signs and symptoms, and knowledge of each disease is necessary for the clinician to provide proper management.

Novel methods of applying direct chemical and mechanical stimulation to the oral mucosa for traditional behavioral pain assays in conscious rats

“…Stomatitis and oral cancer induce severe pain (Lam and Schmidt, 2011;Leao et al, 2007). Oral mucosal pain is triggered by pungent food and physical contact during eating and swallowing (Donnelly et al, 2003;Trotti et al, 2003).…”

Topical Aloe Vera (Aloe barbadensis Miller) Extract Does Not Accelerate the Oral Wound Healing in Rats

“…Usually, they present traumatic or autoimmune etiology (Chavan et al, 2012;Felix et al, 2012;Leão et al, 2007). The treatment of these mouth ulcers has not been fully established, and several protocols using topical or systemic drugs have been described (Chavan et al, 2012;Felix et al, 2012;Leão et al, 2007). Frequently, the aim is to relieve symptoms and accelerate the repair of ulceration to allow tissue reconstitution (Mandelbaum et al, 2003;Eming et al, 2007;de Carvalho et al, 2015).…”

Clinical case of a male patient with oral ulcerative lesions due to eppstein-barr virus and cytomegalovirus

“…Some Viral infections, particularly HSV1, HSV2, and, more rarely, EBV and CMV, etc. In the presence of a state of immunodeficiency or lack of sufficient levels of folic acid, may be induced some superficial oral ulcers, often associated with labial manifestations (6,7).…”