Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars

Jo, Hang-Hyun; Youn, Hyungjun; Lee, Seonghwan; Ban, Changill

doi:10.1039/c4tb00643g

Cited by 44 publications

(36 citation statements)

References 43 publications

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“…Dark-fi eld microscopy showed that the biocompatible gold nanoparticles were easily internalized and most of them localized within the cells. Jo et al performed the PEGylation of GNS synthesized by seed growth with bifunctional O -[2-(3-mercaptopropionylamino)ethyl]-O ′-methylpolyethylene glycol [ 60 ]. These PEGylated gold nanostars were further conjugated with aptamers for the targeting of prostate cancer cells.…”

Section: Pegylation Of Gnsmentioning

confidence: 98%

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Gold Nanostar Synthesis and Functionalization with Organic Molecules

Pallavicini

Cabrini

Borzenkov

2015

SpringerBriefs in Materials

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Section: Pegylation Of Gnsmentioning

confidence: 98%

“…Novel valuable therapeutic complexes, namely dual-aptamermodifi ed gold nanostars, for the targeting of prostate cancers have been developed recently [ 60 ]. The aptamers were conjugated to PEGylated GNS via disulfi de bonds.…”

Section: Other Examples Of Functionalization Of Gnsmentioning

confidence: 99%

Gold Nanostar Synthesis and Functionalization with Organic Molecules

Pallavicini

Cabrini

Borzenkov

2015

SpringerBriefs in Materials

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“…Jo et al developed novel valuable therapeutic complexes, namely dual-aptamermodifi ed GNS, for the targeting of prostate cancers, including PSMA(+) and PSMA(−) cells [ 46 ]. The synthesized probes were subsequently analyzed for cytotoxicity tests, cell uptake, and in vitro photothermal therapy.…”

Section: Application Of Gns For Thermal Therapymentioning

confidence: 99%

Applications of Gold Nanostars: Nanosensing, Thermal Therapy, Delivery Systems

et al. 2015

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This chapter focuses on the most relevant applications of GNS in life science. The versatility of the GNS functionalization is combined with their optical properties to provide promising and prospective approaches in a variety of biomedical fi elds. Nanosensing assays, thermal treatments, and delivery systems based on GNS are discussed in this chapter. Keywords SERS-based sensing • Hyperthermia • Photothermal effect • Smart deliveryFunctionalized gold nanoparticles with controlled geometrical and optical properties are the subject of intensive studies and biomedical applications, including genomics, biosensors, immunoassays, clinical chemistry, laser phototherapy of cancer cells and tumors, and delivery platforms. In these fi elds targeted delivery of drugs, DNA, and antigens is coupled to optical bioimaging and the possibility to monitor cells and image details of tissues with the use of state-of-the-art detection systems [ 1 ]. Nonspherical gold nanoparticles are particularly interesting due to their capability to release locally heat with large effi ciency when they are irradiated in the NIR region of the spectrum [ 2 ]. In addition their size and the shape anisotropy essentially determine the position and the amplitude of the NIR-localized surface plasmon resonance [ 3 ]. The shape of the gold nanostars (GNS), in particular, can be tuned from the shape of sea urchin to that of planar, highly regular penta-branched stars [ 4 ]. The NIR-localized surface plasmon resonance of GNS can be consequently tuned in a wide NIR range up to 1250 nm by varying the axial ratio of protruding branches and multiple LSPR band in the NIR can also be obtained [ 4 ]. The possibility to easily decorate the surface of GNS, in combination with their optical properties

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“…CTAB-free, biocompatible, single-crystalline nanoprisms have been reported, [ 142 ] as well as their application to in vivo photothermal cell ablation of Hydra vulgaris. [ 146 ] Dual aptamer-modifi ed Au NSs presented high selectivity toward prostate cancer cells, through accumulation in PSMA(+) and PSMA(-) cells, and highly effi cient therapy was achieved using an 808 nm laser under an irradiance of 0.3 W cm −2 , which is below the permitted value for skin exposure (0.329 W cm −2 ). Recent interest has been directed toward nanoparticle morphologies containing sharp edges and tips, as these have been demonstrated to display highly active LSPRs, [ 144 ] which are favorable for heat generation, meaning that so-called Au nanostars (Au NSs) are also suitable candidates as nanoheaters.…”

Section: Progress Reportmentioning

confidence: 99%

Modern Applications of Plasmonic Nanoparticles: From Energy to Health

Aberasturi

Serrano-Montes

Liz‐Marzán

2015

Advanced Optical Materials

250

199

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PROGRESS REPORTdisciplines. Besides energy applications, plasmonic nanoparticles have also garnered extraordinary interest in biomedical research. An important example here is the demonstration that the strong photothermal response of plasmonic nanoparticles renders them potential cancer cell and tumor killers. Plasmonic photothermal therapy may thus provide a breakthrough in medicine with large-scale benefi ts for global health.In this progress report, we highlight several relevant applications of plasmonics in the areas of energy and health, two distinct fi elds that, even if they seem unrelated, can profi t from the same phenomenon: LSPR translated into energy harvesting and heat generation. Plasmon-enhanced solar-energy harvesting, solar steam nanobubble generation, plasmonic-enabled photothermal therapy, and light-controlled drug release are discussed, in the context of their emerging technological interest and, therefore, their benefi ts for society.

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Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars

Abstract: A novel general platform for disease-specific photothermal therapy. This is the first demonstration of gold nanostars with tremendous efficiency and impressive selectivity for the targeted cancer, particularly the simultaneous targeting of PSMA(+) and PSMA(−) prostate cancers.

Cited by 44 publications

References 43 publications

Gold Nanostar Synthesis and Functionalization with Organic Molecules

Gold Nanostar Synthesis and Functionalization with Organic Molecules

Applications of Gold Nanostars: Nanosensing, Thermal Therapy, Delivery Systems

Modern Applications of Plasmonic Nanoparticles: From Energy to Health

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