Ultra-sensitive nano- molecular imprinting polymer-based electrochemical sensor for Follicle-Stimulating Hormone (FSH) detection

Pareek, Sakshi; Jain, Utkarsh; Balayan, Sapna; Chauhan, Nidhi

doi:10.1016/j.bej.2021.108329

Cited by 30 publications

(7 citation statements)

References 34 publications

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“…First, the rGO was deposited on the SPE by using a potential range of 0.5 to −1.5 for 6 cycles at a 50 mV/sec scan rate. Again, the gold nanomaterial was deposited through electrodeposition at a 50 mV/s scan rate with a 0.3 to −0.5 potential range for 5 cycles [ 42 , 43 ].…”

Section: Methodsmentioning

confidence: 99%

Fabrication of a Molecularly Imprinted Nano-Interface-Based Electrochemical Biosensor for the Detection of CagA Virulence Factors of H. pylori

Murti

Yang

et al. 2022

Biosensors

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H. pylori is responsible for several stomach-related diseases including gastric cancer. The main virulence factor responsible for its establishment in human gastric cells is known as CagA. Therefore, in this study, we have fabricated a highly sensitive MIP-based electrochemical biosensor for the detection of CagA. For this, an rGO and gold-coated, screen-printed electrode sensing platform was designed to provide a surface for the immobilization of a CagA-specific, molecularly imprinted polymer; then it was characterized electrochemically. Interestingly, molecular dynamics simulations were studied to optimize the MIP prepolymerization system, resulting in a well-matched, optimized molar ratio within the experiment. A low binding energy upon template removal indicates the capability of MIP to recognize the CagA antigen through a strong binding affinity. Under the optimized electrochemical experimental conditions, the fabricated CagA-MIP/Au/rGO@SPE sensor exhibited high sensitivity (0.275 µA ng−1 mL−1) and a very low limit of detection (0.05 ng mL−1) in a linear range of 0.05–50 ng mL−1. The influence of other possible interferents in analytical response has also been observed with the successful determination of the CagA antigen.

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Section: Methodsmentioning

confidence: 99%

Fabrication of a Molecularly Imprinted Nano-Interface-Based Electrochemical Biosensor for the Detection of CagA Virulence Factors of H. pylori

Murti

Yang

et al. 2022

Biosensors

Self Cite

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“…These nanocapsules have exhibited effective release of FSH both in vitro and in vivo, indicating promising prospects for optimizing ovarian reserve function. Furthermore, conceptual investigations have explored the utilization of targeted nanoparticle carriers for controlled FSH release in order to ameliorate fertility outcomes in polycystic ovary syndrome [ 110 ]. Encouraging results highlight the potential viability of these nanoparticle carriers as a therapeutic strategy for polycystic ovary syndrome.…”

Section: Application Of Nanotechnology In the Treatment Of Female Rep...mentioning

confidence: 99%

The utilization of nanotechnology in the female reproductive system and related disorders

Luo,

Jia,

Xing

et al. 2024

Heliyon

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“…The material showed fast and excellent sensitivity to FSH. Furthermore, Pareek et al constructed a novel nanomaterial (NiCo2O4/rGO)-modified indium tin oxide (ITO) electrode for the detection of FSH [ 137 ]. The biosensor could help to overcome the disadvantages of current FSH detection methods, such as high cost, long time consumption and low sensitivity, while also providing a dynamic detection range (0.1 pM–1 µM) and a low detection limit (0.1 pM).…”

Section: Biomaterials For the Evaluation Of Ovarian Agingmentioning

confidence: 99%

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

Guo

Wei

et al. 2022

J Nanobiotechnol

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Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years, various strategies have been developed to preserve fertility in women, while there are currently no clinical treatments to delay ovarian aging. Recently, advances in biomaterials and technologies, such as three-dimensional (3D) printing and microfluidics for the encapsulation of follicles and nanoparticles as delivery systems for drugs, have shown potential to be translational strategies for ovarian aging. This review introduces the research progress on the mechanisms underlying ovarian aging, and summarizes the current state of biomaterials in the evaluation and treatment of ovarian aging, including safety, potential applications, future directions and difficulties in translation. Graphical Abstract

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Ultra-sensitive nano- molecular imprinting polymer-based electrochemical sensor for Follicle-Stimulating Hormone (FSH) detection

Cited by 30 publications

References 34 publications

Fabrication of a Molecularly Imprinted Nano-Interface-Based Electrochemical Biosensor for the Detection of CagA Virulence Factors of H. pylori

Fabrication of a Molecularly Imprinted Nano-Interface-Based Electrochemical Biosensor for the Detection of CagA Virulence Factors of H. pylori

The utilization of nanotechnology in the female reproductive system and related disorders

Biomaterials and advanced technologies for the evaluation and treatment of ovarian aging

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