Ultraviolet (UV) filters are of great concern due to
their wide
occurrence, bioaccumulation, and toxicity. Little is known about human
exposure to UV filters. A total of 3467 individual human milk samples
from 24 Chinese provinces were collected during 2017–2019.
The concentrations of 12 UV filters in 100 pooled milk samples were
determined. The total UV filter concentration was 78–846 (mean
235 ± 120) ng/g lipid weight. The highest and lowest total mean
concentrations were for samples from Qinghai and Sichuan provinces,
respectively. A significant positive correlation was found between
UV radiation levels and UV concentrations in the samples. The dominant
UV filters were 2-(2-hydroxy-5-methylphenyl) benzotriazole (UV-P)
and ethylhexyl methoxycinnamate (EHMC), which contributed means of
32 and 22%, respectively, to the total concentrations. Plastic products
and sunscreens were probably the sources of UV-P and EHMC in the human
milk from China, respectively. The mean 2-(3,5-di-tert-amyl-2-hydroxyphenyl) benzotriazole (UV-328) concentration was 2.6
± 2.6 ng/g lipid weight. The UV filter profiles were similar
to profiles for samples from Japan, the Philippines, and Switzerland
but not for samples from Korea and Vietnam. The estimated daily UV
filter intake for breastfed infants was below the corresponding reference
dose. This was the first large-scale study of UV filters in human
milk and will help assess the risks posed.