Ultracompact Three-Dimensional Tubular Conductivity Microsensors for Ionic and Biosensing Applications

Martínez-Cisneros, Cynthia S.; Sánchez, Samuel; Xi, Wang; Schmidt, Oliver G.

doi:10.1021/nl500795k

Cited by 54 publications

(54 citation statements)

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“…Self-assembled Swiss roll geometries have been applied to a wide range of rolled-up devices (for example, [37][38][39][40][41][42] ) based on semiconductor, oxide and metal strained layer engineering. However, for antenna applications, metal-based strained layers are not appropriate because of signal screening.…”

Section: Resultsmentioning

confidence: 99%

Compact helical antenna for smart implant applications

2015

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Smart implants are envisioned to revolutionize personal health care by assessing physiological processes, for example, upon wound healing, and communicating these data to a patient or medical doctor. The compactness of the implants is crucial to minimize discomfort during and after implantation. The key challenge in realizing small-sized smart implants is high-volume cost-and time-efficient fabrication of a compact but efficient antenna, which is impedance matched to 50 Ω, as imposed by the requirements of modern electronics. Here, we propose a novel route to realize arrays of 5.5-mm-long normal mode helical antennas operating in the industry-scientific-medical radio bands at 5.8 and 2.4 GHz, relying on a self-assembly process that enables large-scale high-yield fabrication of devices. We demonstrate the transmission and receiving signals between helical antennas and the communication between an antenna and a smartphone. Furthermore, we successfully access the response of an antenna embedded in a tooth, mimicking a dental implant. With a diameter of~0.2 mm, these antennas are readily implantable using standard medical syringes, highlighting their suitability for in-body implant applications.

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Section: Resultsmentioning

confidence: 99%

Compact helical antenna for smart implant applications

2015

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“…Different patterns of holes are shown in Fig. 46 After rolling up, a short membrane created a porous tube with a few (<2) windings (Fig. 1B (circular shape) and D (rectangular shape).…”

Section: Resultsmentioning

confidence: 99%

Tailoring three-dimensional architectures by rolled-up nanotechnology for mimicking microvasculatures

et al. 2015

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Artificial microvasculature, particularly as part of the blood-brain barrier, has a high benefit for pharmacological drug discovery and uptake regulation. We demonstrate the fabrication of tubular structures with patterns of holes, which are capable of mimicking microvasculatures. By using photolithography, the dimensions of the cylindrical scaffolds can be precisely tuned as well as the alignment and size of holes. Overlapping holes can be tailored to create diverse three-dimensional configurations, for example, periodic nanoscaled apertures. The porous tubes, which can be made from diverse materials for differential functionalization, are biocompatible and can be modified to be biodegradable in the culture medium. As a proof of concept, endothelial cells (ECs) as well as astrocytes were cultured on these scaffolds. They form monolayers along the scaffolds, are guided by the array of holes and express tight junctions. Nanoscaled filaments of cells on these scaffolds were visualized by scanning electron microscopy (SEM). This work provides the basic concept mainly for an in vitro model of microvasculature which could also be possibly implanted in vivo due to its biodegradability.

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“…Inorganic rolled-up microtubes less than 10 µm in diameter have previously been shown to act as ultracompact microfl uidic channels with fully integrated electrodes and fi eld effect transistors, able to detect polar and ionic fl uids down to subnanomolar concentrations, sense single cancer cells, and guide neuronal outgrowth. [20][21][22] Medical applications of such tubular architectures have been envisioned for topographically mediated nerve growth, tissue engineering, and regeneration. [ 22 ] The opportunity to open/close such microscale devices upon external stimulation brings these applications closer to reality and is particularly appealing for neuronal cuff implant applications to enclose and guide the growth of nervous fi bers with a typical size of 10-50 µm.…”

Section: Doi: 101002/adma201503696mentioning

confidence: 99%