Ultrafine agarose-coated superparamagnetic iron oxide nanoparticles (AC-SPIONs): a promising sorbent for drug delivery applications

Adivi, Fatemeh Ghanbari; Hashemi, Payman

doi:10.1007/s13738-018-1311-5

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…They should also be able to respond to stimuli if possible. Two studies have recently demonstrated these criteria [ 47 , 56 ]. Specifically, Ghanbari Adivi and colleagues [ 47 ] used ultrafine agarose, a natural biopolymer known to be biocompatible, to coat superparamagnetic iron oxide nanoparticles (AC-SPIONs), epoxy-activated by epichlorohydrin and aminated by ammonium hydroxide in a one-step method to purify gallic and ellagic acids.…”

Section: Separation and Purification Of Proteins By Mnpsmentioning

confidence: 99%

“…Two studies have recently demonstrated these criteria [ 47 , 56 ]. Specifically, Ghanbari Adivi and colleagues [ 47 ] used ultrafine agarose, a natural biopolymer known to be biocompatible, to coat superparamagnetic iron oxide nanoparticles (AC-SPIONs), epoxy-activated by epichlorohydrin and aminated by ammonium hydroxide in a one-step method to purify gallic and ellagic acids. The results obtained showed that the functionalized AC-SPIONs possess great adsorptive and in vitro drug release properties in phosphate-buffered saline at a pH of 7.4.…”

Section: Separation and Purification Of Proteins By Mnpsmentioning

confidence: 99%

“…The results obtained showed that the functionalized AC-SPIONs possess great adsorptive and in vitro drug release properties in phosphate-buffered saline at a pH of 7.4. The results indicate AC-SPIONs as applicable in magnetic solid-phase extraction, drug delivery, protein purification, and enzyme immobilization techniques [ 47 ]. The other authors [ 56 ] used a diblock copolymer of poly(acrylic acid)-block-poly( N -isopropylacrylamide) ( p AAc-b- p NIPAAm) to complex iron cations (Fe 2+ /Fe 3+ ) in water followed by adding NH 4 OH to induce the formation of the iron oxide particles.…”

Section: Separation and Purification Of Proteins By Mnpsmentioning

confidence: 99%

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State of the art on the separation and purification of proteins by magnetic nanoparticles

Le,

Suttikhana,

Ashaolu

2023

J Nanobiotechnol

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The need for excellent, affordable, rapid, reusable and biocompatible protein purification techniques is justified based on the roles of proteins as key biomacromolecules. Magnetic nanomaterials nowadays have become the subject of discussion in proteomics, drug delivery, and gene sensing due to their various abilities including rapid separation, superparamagnetism, and biocompatibility. These nanomaterials also referred to as magnetic nanoparticles (MNPs) serve as excellent options for traditional protein separation and analytical methods because they have a larger surface area per volume. From ionic metals to carbon-based materials, MNPs are easily functionalized by modifying their surface to precisely recognize and bind proteins. This review excavates state-of-the-art MNPs and their functionalizing agents, as efficient protein separation and purification techniques, including ionic metals, polymers, biomolecules, antibodies, and graphene. The MNPs could be reused and efficaciously manipulated with these nanomaterials leading to highly improved efficiency, adsorption, desorption, and purity rate. We also discuss the binding and selectivity parameters of the MNPs, as well as their future outlook. It is concluded that parameters like charge, size, core–shell, lipophilicity, lipophobicity, and surface energy of the MNPs are crucial when considering protein selectivity, chelation, separation, and purity. Graphical abstract

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Section: Separation and Purification Of Proteins By Mnpsmentioning

confidence: 99%

Section: Separation and Purification Of Proteins By Mnpsmentioning

confidence: 99%

Section: Separation and Purification Of Proteins By Mnpsmentioning

confidence: 99%

See 1 more Smart Citation

State of the art on the separation and purification of proteins by magnetic nanoparticles

Le,

Suttikhana,

Ashaolu

2023

J Nanobiotechnol

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“…Polysaccharides are often employed as colloidal stabilizers of magnetic nanoparticles during synthesis and for surface modification [ 112 – 114 ], as they are biocompatible, non-toxic, renewable and contain functional groups that allow further functionalization [ 79 ]. The most common polysaccharides employed for surface modifications are agarose, alginate, chitosan, dextran, hyaluronic acid, heparin, pullulan, starch and carrageenan [ 115 ].…”

Section: Ionps As Adsorbents Of Biomoleculesmentioning

confidence: 99%

Bio-nano interactions: binding proteins, polysaccharides, lipids and nucleic acids onto magnetic nanoparticles

2021

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The major interest in nanoparticles as an application platform for biotechnology arises from their high surface-to-volume ratio. Iron oxide nanoparticles (IONPs) are particularly appealing due to their superparamagnetic behavior, which enables bioseparation using external magnetic fields. In order to design advanced biomaterials, improve binding capacities and develop innovative processing solutions, a thorough understanding of the factors governing organic-inorganic binding in solution is critical but has not yet been achieved, given the wide variety of chemical and physical influences. This paper offers a critical review of experimental studies of the interactions between low cost IONPs (bare iron oxides, silica-coated or easily-functionalized surfaces) and the main groups of biomolecules: proteins, lipids, nucleic acids and carbohydrates. Special attention is devoted to the driving forces and interdependencies responsible of interactions at the solid-liquid interface, to the unique structural characteristics of each biomolecular class, and to environmental conditions influencing adsorption. Furthermore, studies focusing on mixtures, which are still rare, but absolutely necessary to understand the biocorona, are also included. This review concludes with a discussion of future work needed to fill the gaps in knowledge of bio-nano interactions, seeking to improve nanoparticles’ targeting capabilities in complex systems, and to open the door for multipurpose recognition and bioseparation processes.

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ZIF-based boronic acid modified molecular imprinted polymers in combination with silver nanoparticles/glutathione coated graphene oxide adsorbent for the selective enrichment of ellagic acid

Gao,

Bi,

Chai

et al. 2024

Journal of Chromatography A

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Ultrafine agarose-coated superparamagnetic iron oxide nanoparticles (AC-SPIONs): a promising sorbent for drug delivery applications

Cited by 5 publications

References 23 publications

State of the art on the separation and purification of proteins by magnetic nanoparticles

State of the art on the separation and purification of proteins by magnetic nanoparticles

Bio-nano interactions: binding proteins, polysaccharides, lipids and nucleic acids onto magnetic nanoparticles

ZIF-based boronic acid modified molecular imprinted polymers in combination with silver nanoparticles/glutathione coated graphene oxide adsorbent for the selective enrichment of ellagic acid

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