Ultrahigh‐Field Multimodal MRI Assessment of Muscle Damage

Fouré, Alexandre; Pini, Lauriane; Rappacchi, Stanislas; Ogier, Augustin C.; Mattei, Jean‐Pierre; Bydder, Mark; Guye, Maxime; Bendahan, David

doi:10.1002/jmri.26222

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…More specific to muscle microstructure assessment, diffusion tensor imaging changes related to intramuscular water diffusion within the tissue have been detected after NMES-induced muscle damage. Increased radial diffusion of water molecules within the directly stimulated muscle was reported, providing indirect evidence of damage to cellular barriers (20,39). These macroscopic changes assessed by MRI were further confirmed by histological analyses from muscle biopsies obtained after the NMES session.…”

Section: Changes In Muscle Structurementioning

confidence: 68%

“…Although the role of the calcium-calpain pathway in voluntary lengthening contraction-induced muscle damage has been widely documented (at least in animals; see review of Allen et al (52)), there is, so far, no information on its potential contribution to the severe muscle damage resulting from NMES-evoked isometric submaximal contractions. Moreover, an increased intracellular sodium concentration was reported in a clinical case after NMES-evoked submaximal isometric contractions (39), which could explain the changes in pH homeostasis (41). Further studies are needed to determine whether, and to what extent, intracellular calcium/sodium accumulation plays a role in the severity of muscle tissue damage.…”

Section: The Potential Role Of Ion Disturbancesmentioning

confidence: 98%

“…NMES-evoked submaximal isometric contractions could generate severe damage to sarcolemma, leading to the dysregulation of pH through the impaired activity of the Na + /H + exchangers (42). Interestingly, sodium accumulation in damaged muscle has been recently described in a case study (39). Impaired mitochondrial function, illustrated by a slower PCr recovery rate and significantly decreased total rate of adenosine triphosphate (ATP) production during a standardized rest-exercise-recovery protocol, has also been reported (41).…”

Section: Cellular Metabolic and Biochemical Alterationsmentioning

confidence: 99%

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Skeletal Muscle Damage Produced by Electrically Evoked Muscle Contractions

Fouré

Gondin

2020

Exercise and Sport Sciences Reviews

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Understanding the physiological/mechanical mechanisms leading to skeletal muscle damage remains one of the challenges in muscle physiology. This review presents the functional, structural, and cellular consequences of electrically evoked submaximal isometric contractions that can elicit severe and localized skeletal muscle damage. Hypotheses related to underlying physiological and mechanical processes involved in severe and localized muscle damage also are discussed.

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Section: Changes In Muscle Structurementioning

confidence: 68%

Section: The Potential Role Of Ion Disturbancesmentioning

confidence: 98%

Section: Cellular Metabolic and Biochemical Alterationsmentioning

confidence: 99%

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Skeletal Muscle Damage Produced by Electrically Evoked Muscle Contractions

Fouré

Gondin

2020

Exercise and Sport Sciences Reviews

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“…Previous work showed that DTI facilitated detection of structural changes in muscle beyond conventional T2weighted MRI [10]. Also, research performed in injured athletes showed that DTI has the potential for the assessment of muscle injuries [11,12].…”

Section: Introductionmentioning

confidence: 99%

The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults

et al. 2019

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Objectives Assessment of the repeatability of diffusion parameter estimations in the upper leg muscles of healthy adults over the time course of 2 weeks, from a simultaneous bilateral upper leg DTI measurement. Methods SE-EPI DTI datasets were acquired at 3 T in the upper legs of 15 active adults at a time interval of 2 weeks. ROIs were manually drawn for four quadriceps and three hamstring muscles of both legs. The following DTI parameters were analyzed: 1st, 2nd, and 3rd eigenvalue (λ 1 , λ 2 , and λ 3), mean diffusivity (MD), and fractional anisotropy (FA). DTI parameters per muscle were calculated with and without intravoxel incoherent motion (IVIM) correction together with SNR levels per muscle. Bland-Altman plots and within-subject coefficient of variation (wsCV) were calculated. Left-right differences between muscles were assessed. Results The Bland-Altman analysis showed good repeatability of all DTI parameters except FA for both the IVIM-corrected and standard data. wsCV values show that MD has the highest repeatability (4.5% IVIM; 5.6% standard), followed by λ 2 (4.9% IVIM; 5.5% standard), λ 1 (5.3% IVIM; 7.5% standard), and λ 3 (5.7% IVIM; 5.7% standard). wsCV values of FA were 15.2% for the IVIM-corrected data and 13.9% for the standard analysis. The SNR (41.8 ± 16.0 right leg, 41.7 ± 17.1 left leg) and wsCV values were similar for the left and right leg and no left-right bias was detected. Conclusions Repeatability was good for standard DTI data and slightly better for IVIM-corrected DTI data. Our protocol is suitable for DTI of the upper legs with overall good SNR. Key Points • The presented DTI protocol is repeatable and therefore suitable for bilateral DT imaging of the upper legs. • Additional B1 + calibrations improve SNR and repeatability. • Correcting for perfusion effects improves repeatability. Keywords Diffusion tensor imaging. Magnetic resonance imaging. Hamstring muscles. Quadriceps muscle Abbreviations BFL Left biceps femoris long head BFR Right biceps femoris long head IVIM Intravoxel incoherent motion MD Mean diffusivity RFL Left rectus femoris RFR Right rectus femoris ROI Region of interest SML Left semimembranosus SMR Right semimembranosus SNR Signal-to-noise ratio STL Left semitendinosus STR Right semitendinosus VIL Left vastus intermedius VIR Right vastus intermedius Electronic supplementary material The online version of this article (

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“…22,42 Indeed, EIMD is related to the mechanical constraints imposed by exercise on muscle tissue but also to the physiological events following the initial damage leading to additional structural alterations. 22,42 Therefore, the changes in the skeletal muscle biochemical environment 43 and microstructural organization 7 could contribute to the decrease in resting skeletal muscles' mechanical properties. The duration of the exercise appears to be a key factor to explain the contrasting results assessed in the present study after short and long races.…”

Section: Effects Of Mountain Ultra-marathonmentioning

confidence: 99%

Sex‐related differences and effects of short and long trail running races on resting muscle‐tendon mechanical properties

Fouré

Besson

Stauffer

et al. 2022

Scandinavian Med Sci Sports

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The purpose of the study was to assess sex‐related differences in resting mechanical properties and adaptations of skeletal muscles and tendons in response to trail running races of different distances using multi‐site shear wave elastography assessments of the lower limb, force capacity and blood analyses. Sex differences in resting mechanical properties of knee extensor and plantar flexor muscles and tendons were characterized by shear wave velocity (SWV) measurements in healthy males (N = 42) and females (N = 25) trained in long‐distance running. Effects of running distance on muscle and tendon properties were assessed in short (<60 km, N = 23) vs. long (>100 km, N = 26) distance races. Changes in isometric maximal voluntary contraction torque, serum C‐reactive protein and creatine kinase activity were also quantified after running races. Higher SWV of relaxed triceps surae muscle was detected in females as compared to males before running races (+4.8%, p = 0.006), but the significant increases in triceps surae muscle group (+7.0%, p = 0.001) and patellar tendon SWV (+15.4%, p = 0.001) after short‐distance races were independent of sex. A significant decrease in triceps surae muscle SWV was found after long‐distance races in the whole experimental population (−3.1%, p = 0.049). Post‐races increase in C‐reactive protein and creatine kinase activity were significantly correlated to the relative decreases in triceps surae and quadriceps femoris skeletal muscle SWV (ρ = −0.56, p = 0.001 and ρ = −0.51, p = 0.001, respectively). Resting mechanical properties of muscles and tendons are affected by sex, and adaptations to trail races are related to running distance. Exercise‐induced changes in resting skeletal muscle mechanical properties are associated with enhanced indirect markers of inflammation and muscle damage.

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Ultrahigh‐Field Multimodal MRI Assessment of Muscle Damage

Cited by 5 publications

References 10 publications

Skeletal Muscle Damage Produced by Electrically Evoked Muscle Contractions

Skeletal Muscle Damage Produced by Electrically Evoked Muscle Contractions

The repeatability of bilateral diffusion tensor imaging (DTI) in the upper leg muscles of healthy adults

Sex‐related differences and effects of short and long trail running races on resting muscle‐tendon mechanical properties

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