Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber

Bourquin, Stéphane; Aguirre, Aaron D.; Hartl, Ingmar; Hsiung, Pei–Lin; Ko, Tony H.; Fujimoto, James G.; Birks, T. A.; Wadsworth, William J.; Bünting, Udo; Kopf, D.

doi:10.1364/oe.11.003290

Cited by 104 publications

(62 citation statements)

References 19 publications

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“…The standard spectral range of conventional ophthalmic OCT has been between 700 and 900 nm where the humors in the eye are transparent and broadband super-luminescent-diode (SLD) light sources are readily available [13,14]. Recent studies have suggested that the 1040-nm spectral range [15][16][17] could be a viable alternative operating window for retinal imaging and potentially could offer deeper penetration into the choroid below the highly absorbing and scattering retinal pigment epithelium [15]. Spectral domain (SD) OCT, also known as Fourier domain OCT, using broadband light sources at 800 nm and spectrometers has been developed to enable three-dimensional retinal imaging in vivo with superior image acquisition speed and sensitivity to conventional time-domain OCT [18,19].…”

Section: Introductionmentioning

confidence: 99%

In vivo optical frequency domain imaging of human retina and choroid

Lee¹,

Boer²,

Mujat³

et al. 2006

Opt. Express

167

112

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Optical frequency domain imaging (OFDI) using swept laser sources is an emerging second-generation method for optical coherence tomography (OCT). Despite the widespread use of conventional OCT for retinal disease diagnostics, until now imaging the posterior eye segment with OFDI has not been possible. Here we report the development of a highperformance swept laser at 1050 nm and an ophthalmic OFDI system that offers an A-line rate of 18.8 kHz, sensitivity of >92 dB over a depth range of 2.4 mm with an optical exposure level of 550 μ W, and deep penetration into the choroid. Using these new technologies, we demonstrate comprehensive human retina, optic disc, and choroid imaging in vivo. This advance enables us to view choroidal vasculature in vivo without intravenous injection of fluorescent dyes and may provide a useful tool for evaluating choroidal as well as retinal diseases.

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Section: Introductionmentioning

confidence: 99%

In vivo optical frequency domain imaging of human retina and choroid

Lee¹,

Boer²,

Mujat³

et al. 2006

Opt. Express

167

112

View full text Add to dashboard Cite

show abstract

“…The transmitted beam is coupled into a 50-m conventional single mode fiber (SMF), which has a mode field diameter of 5.6 μm. A broadened spectrum of 40 nm FWHM due to self-phase modulation [10][11][12] was obtained.…”

Section: Experimental Setup 21 Light Sourcementioning

confidence: 99%

Megahertz streak-mode Fourier domain optical coherence tomography

et al. 2011

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“…For example, the compact diode-pumped femtosecond Nd:glass laser (High Q Laser Productions) can generate pulse durations of <100 fs at repetition rates of $50 MHz with average powers of $100 mW. Nonlinear self phase modulation in a high numerical aperture fiber can be used to generate bandwidths of >200 nm centered around 1,050 nm [77]. The measured FWHM of the point spread function is 4.2 mm in air, corresponding to 3.5 mm in tissue.…”

Section: 5mentioning

confidence: 99%